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Heart ; 102(6): 465-71, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26762238

ABSTRACT

BACKGROUND: Levosimendan is an inotropic agent with cardioprotective and vasodilating properties used for the management of acutely decompensated heart failure. We studied the effects of levosimendan treatment on the size of myocardial infarction (MI) and left ventricular (LV) function in experimental pig model of post MI heart failure. METHODS: After occlusion of the left anterior descending (LAD) coronary artery, animals received levosimendan 5 mg/kg/day orally for 8 weeks (n=7) or no treatment (n=18). One week after stopping treatment, transthoracic echocardiography, CT scan and positron emission tomography were performed to evaluate myocardial function, perfusion and oxidative metabolism. Histology was used to confirm the size of MI and features of LV remodelling. RESULTS: The size of MI was significantly smaller in the levosimendan group than in the controls (12±13% vs 27±15% of the LV, p=0.03). End-diastolic volume (EDV) and end-systolic volume (ESV) were smaller in the levosimendan than in the control group (EDV 161±29 mL vs 245±84 mL, p=0.06; ESV 81±18 mL vs 149±67 mL, p=0.03), whereas ejection fraction tended to be higher in the levosimendan group (50±6% vs 41±8%, p=0.06). CONCLUSIONS: Eight weeks of levosimendan therapy after recent LAD occlusion decreases the size of MI and leads to better preservation of LV function as well as reduced LV remodelling.


Subject(s)
Coronary Occlusion/complications , Hydrazones/therapeutic use , Myocardial Contraction/drug effects , Myocardial Infarction/drug therapy , Myocardium/pathology , Pyridazines/therapeutic use , Ventricular Function, Left/drug effects , Ventricular Remodeling/drug effects , Acute Disease , Animals , Cardiotonic Agents/therapeutic use , Diastole , Disease Models, Animal , Follow-Up Studies , Male , Myocardial Contraction/physiology , Myocardial Infarction/etiology , Myocardial Infarction/physiopathology , Simendan , Stroke Volume/drug effects , Stroke Volume/physiology , Swine , Systole , Ventricular Function, Left/physiology
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