ABSTRACT
Clinical-laboratory investigations in 58 patients with peptic ulcer have shown that increased production of the intestinal hormones of the chromophine system of the gastrointestinal tract is of great significance in pathogenesis of dumping syndrome after Billroth-II resection of the stomach.
Subject(s)
Dumping Syndrome/etiology , Gastrectomy/adverse effects , Adult , Aged , Biopsy , Disease Progression , Dumping Syndrome/diagnosis , Dumping Syndrome/metabolism , Duodenal Ulcer/surgery , Endoscopy, Gastrointestinal , Female , Follow-Up Studies , Gastrointestinal Hormones/metabolism , Humans , Intestinal Mucosa/metabolism , Intestinal Mucosa/ultrastructure , Male , Microscopy, Electron , Middle Aged , Prognosis , Risk Factors , Serotonin/metabolism , Stomach Ulcer/surgery , Young AdultABSTRACT
The aim of the study was the evaluation of efficacy of the resection with pyloric retention proposed by the authors as a method for prevention of post gastroresectional damping syndrome in patients with ulcers. Resection with pyloric retention is performed in six modifications of three basic methods of resections. We have the experience of using this approach in 712 clinical cases. Among them 237 were women and 475 were men 19-75 years of age. It was shown that resection with pyloric retention provides rhythmic evacuation and prevents development of damping syndrome and duodenal reflux. It was found that the main reasons of the development of postgastroresectional syndromes include wide-area mobilization of the stomach and resection of the small curvature, which induce insufficiency of cardia, atony, chronic disturbances of the duodenal passing. Due to the retention of pyloric function damping syndrome have been developed only in 3 patients. In all these cases the syndrome was mild. It may be concluded that gastric resection with pyloric retention represents the most "physiological" intervention and has many advantages in comparison with other methods.
