ABSTRACT
The analysis of a large body of heavy ion fusion reaction data with medium-heavy projectiles (6 < or = Z < or = 18) and actinide targets suggests a disappearance of the 3n exit channel with increasing atomic number of the projectile. Here, we report a measurement of the excitation function of the reaction (248)Cm ((26)Mg,xn)(274-x)Hs and the observation of the new nuclide (271)Hs produced in the 3n evaporation channel at a beam energy well below the Bass fusion barrier with a cross section comparable to the maxima of the 4n and 5n channels. This indicates the possible discovery of new neutron-rich transactinide nuclei using relatively light heavy ion beams of the most neutron-rich stable isotopes and actinide targets.
ABSTRACT
Nuclear transformation of the target material is considered as an essential parameter for the specific activity of (177)Lu produced via (176)Lu(n, gamma)(177)Lu nuclear reactions. It is shown that (176)Lu burn-up has to be taken into account to estimate the (177)Lu specific activity related to the total mass or amount of lutetium in the system.
Subject(s)
Isotope Labeling , Lutetium , Radioisotopes , Radiopharmaceuticals/chemical synthesis , Drug Stability , Nuclear ReactorsABSTRACT
Due to its physical and chemical characteristics, 177Lu is a very attractive radionuclide for use in nuclear medicine. This paper introduces a method for a precise calculation of the irradiation yield of 177Lu produced by neutron activation of 176Lu in a nuclear reactor. The calculation is based on the Westcott convention which requires the knowledge of the neutron flux parameters. In this work, the neutron flux parameters of the new research reactor FRM-II (Garching, Germany) were determined and the stability of thermal neutron flux and thermal neutron flux temperature was monitored. The comparison of theoretically calculated and experimentally determined yield for Lu176(n,gamma)Lu177 reaction is presented.
Subject(s)
Lutetium/isolation & purification , Radioisotopes/isolation & purification , Radiopharmaceuticals/isolation & purification , Neutron Activation Analysis , Nuclear ReactorsABSTRACT
OBJECTIVE: The detection of p16 in oncocytology and in the surgical pathology of the uterine cervix. SETTING: Department of Pathology and Department of Gynaecology and Obstetrics, University Hospital Brno. METHODS: An imunocytochemical and immunohistochemical analysis of formalin-fixed, paraffin embedded samples of the uterine cervix (included knips biopsies) and liquid based smears was performed. The bioptic database included 7 cases of CIN II-III, 5 cases of reactive epithelial changes and 3 cases of atrophic epithelium. 36 liquid based smears, 25 cases of CIN III and 11 cases of uterine cervix without a dysplastic lesion. RESULTS: Nuclear and cytoplasmatic p16 positivity was found in 22 cases of CIN III in liquid based smears. Diffuse and intensive p16 expression was in 5 cases of knips biopsies CIN III. CONCLUSION: The detection of p16 seems to be a valuable tool in surgical pathology of the uterine cervix: possible evaluation of the surgical margins, differential diagnosis regarding reactive atypia, and it is also prospective in oncocytologic diagnosis regarding differential diagnosis of the ASCUS, or can be used in monitoring of the uterine cervix dysplasia.
Subject(s)
Cervix Uteri/chemistry , Cyclin-Dependent Kinase Inhibitor p16/analysis , Uterine Cervical Neoplasms/chemistry , Biomarkers/analysis , Diagnosis, Differential , Female , Humans , Immunohistochemistry , Uterine Cervical Dysplasia/chemistry , Uterine Cervical Dysplasia/diagnosis , Uterine Cervical Neoplasms/diagnosisABSTRACT
The laboratory was engaged in exfoliative cytology, mainly of sputa and investigated 1450 hospitalized patients and 1410 smokers in a screening campaign during the last year. Another programme included cytology of bronchoscopical materials (2480 patients a year), fine needle aspiration cytology (550 patients), and peroperation cytology, mostly pulmonary and mammary (125 patients). A limited number of exfoliative and bronchoscopical materials could have been examined in correlation with the number of medical technologists for screening and preliminary evaluation. The laboratory shared immunochemical facilities and computerized registration of results with the others in the Institute. For future, the laboratory reckons with an increase of aspirations taken by visualization methods and with development of special technologies of material processing and evaluation.
