[Effect of carbostimulin on reparative osteogenesis in rabbits of different ages]. / O vliianii karbostimulina na reparativnyi osteogenez u krolikov razlichnogo vozrasta.

Rate of reparative osteogenesis was studied after partial resection of rabbit radius bone. Within 15 days of the restoration period the content of dry residue was increased by 26%, 17% and 35% in regenerate of 2-months old animals, treated with their mixtures as compared with 6-months old rabbits. Content of calcium was increased 1.5-fold in callus of all the 2-months old animals as compared with that in the 6-months old rabbits.

[Effect of carbostimulin and its mixture with vitamin D3 on the mineralization process of the bone callus in rabbits]. / Vliianie karbostimulina i smesi ego s vitaminom D3 na protsess mineralizatsii kostnoi mozoli krolikov.

Mineralization of rabbit bone callus was studied within 15 days after resection of the upper part of radius bone inder conditions of treatment with carbostimuline and its mixture with vitamin D3. Content of calcium in the bone regenerate was increased by 40.8% after administration of carbostimuline and--by 70.5% after treatment with mixture containing vitamin D3. These preparations caused only slight effects on the phosphorus content. Dry residue in the regenerate os f animals, treated with the preparations, was increased approximately 2-fold (43% and 23%, respectively, p less than or equal to 0.001) as compared with control group. Content of citric acid was distinctly higher in the bone tissue of the treated animals. Within 15 days after the operation content of sialic acids wanormalized in blood serum of the animals. The data obtained were corroborated by X-ray and histologic examinations.

[Effect of carbostimulin and vitamin D3 on activity of glycolytic enzymes of rabbit bones, regenerates and muscles]. / Vpliv (karbostimulinu) ta vitaminu D3 na aktivnist' fermentiv glikolizu v tkaninakh regeneratu, kistok ta m'iaziv kroliv.

Activity of glycolysis enzymes such as: phosphofructokinase, aldolase, phosphoglucomutase, was determined in the regenerate of a bone, bone fragments, native bone and, for the sake of comparison, in the animal muscles after the radius resection and feeding of carbostimulin and its mixture with vitamin D3 for 10 days. On the 12th day after the radius resection the phosphofructokinase activity in rabbits increases in the native and operated bones as compared to that in bones of nonoperative animals. In the group of rabbits which were fed on the mixture of carbostimulin and vitamin D3 the phosphofructokinase activity is 7-2 times as high. In the regenerate of these animals the activity becomes 12 times as high as that in the regenerate of the control rabbits. An analogous increase in the aldolase and phosphoglucomutase reaction rate is observed in the bones of the animals which received carbostimulin and vitamin D3 (4.5 and 7.5 times, respectively). The same tendency to the increase in the activity of these enzymes is observed in the regenerate tissue. In the muscular tissue at this stage of regeneration the activity of the studied enzymes which is usually high in norm decreases.