1.
Med Dosw Mikrobiol
; 41(1): 67-70, 1989.
Article
in Polish
| MEDLINE
| ID: mdl-2668662
ABSTRACT
Ten Candida albicans strains were tested for their adherence to buccal epithelial cells in vitro in the presence of synthetic antimycotic drugs as 5-fluorocytosine, clotrimazole and ketoconazole. The drugs when applied in therapeutic concentrations inhibited adherence stronger than when applied in subinhibitory concentrations although in both situations the inhibition was statistically significant in comparison to control experiments without these drugs (p less than 0.01). The highest inhibition of adherence was seen with 5-fluorocytosine and the weakest with clotrimazole. Out of imidazole derived drugs strong inhibition of adherence was achieved with ketoconazole.
Subject(s)
Candida albicans/drug effects , Clotrimazole/pharmacology , Flucytosine/pharmacology , Imidazoles/pharmacology , Ketoconazole/pharmacology , Mouth Mucosa/microbiology , Adhesiveness , Candida albicans/pathogenicity , Epithelium/microbiology , Female , Humans , In Vitro Techniques
2.
Med Dosw Mikrobiol
; 40(4): 238-43, 1988.
Article
in Polish
| MEDLINE
| ID: mdl-3073283