Subject(s)
Crohn Disease/etiology , Crohn Disease/epidemiology , Crohn Disease/psychology , Demography , HumansABSTRACT
We studied reflux of duodenal contents into the stomach in patients with gastric ulcers, patients with duodenal ulcers, and normal subjects. Duodenogastric reflux was assessed in the fasting state and after cholecystokinin octapeptide administration (0.02 micrograms/kg intravenously). Slight reflux was observed in the fasting state in all three groups. However, after cholecystokinin octapeptide administration, reflux was significantly greater in gastric ulcer patients than in control patients for pancreatic phospholipase A2 (p less than 0.01) and lysophosphatidylcholine (p less than 0.001). Also in gastric ulcer patients, the gastric contents were significantly more alkaline (pH 5.26 +/- 0.58, p less than 0.001) during duodenogastric reflux than in normal subjects (pH 3.65 +/- 0.50) or duodenal ulcer patients (pH 2.67 +/- 0.63). Our results suggest that reflux of both pancreatic and biliary secretions might contribute to the gastric mucosal injury in gastric ulcer patients and we postulate that pancreatic phospholipase A2 might have a greater role in this process than has been previously acknowledged.
Subject(s)
Duodenogastric Reflux/etiology , Stomach Ulcer/complications , Adult , Aged , Bile Acids and Salts/metabolism , Cholecystokinin/metabolism , Female , Gastric Juice/physiology , Hemolysis , Humans , Lysophosphatidylcholines/metabolism , Male , Middle Aged , Phospholipases A/metabolism , Phospholipases A2 , Stomach Ulcer/physiopathologySubject(s)
Vitamin E Deficiency , Vitamin E/pharmacology , Animals , Humans , Rats , Vitamin E/metabolism , Vitamin E Deficiency/complicationsSubject(s)
Anemia, Hypochromic/etiology , Angina Pectoris/etiology , Aortic Valve Stenosis/complications , Mitral Valve Stenosis/complications , Adenocarcinoma/complications , Adenocarcinoma/drug therapy , Aged , Anemia, Hypochromic/complications , Colon/diagnostic imaging , Colonic Neoplasms/complications , Colonic Neoplasms/diagnostic imaging , Colonic Neoplasms/drug therapy , Female , Fluorouracil/therapeutic use , Humans , RadiographySubject(s)
Chemical and Drug Induced Liver Injury/etiology , Contraceptives, Oral, Sequential/adverse effects , Contraceptives, Oral/adverse effects , Adult , Alkaline Phosphatase/blood , Aspartate Aminotransferases/blood , Bilirubin/blood , Ethinyl Estradiol/adverse effects , Female , Humans , Norethindrone/adverse effects , Norethindrone/analogs & derivatives , Norethindrone AcetateABSTRACT
Transient pure red-cell aplasia is a rare complication of persistent acute hepatitis. We have investigated possible mechanisms for marrow suppression in one such patient who developed erythroid aplasia in the course of transfusion-related hepatitis. The patient's lymphocytes, obtained during the acute illness, markedly inhibited erythroid colony formation by donor marrow. After the patient recovered, remission lymphocytes in co-culture did not inhibit colony formation. No reversible suppression was demonstrable by addition of patient serum. These observations suggest that hematocytopenias associated with hepatitis may result from cell-mediated suppression induced by hepatic injury.
Subject(s)
Anemia, Aplastic/complications , Erythropoiesis , Hepatitis B/complications , Aged , Anemia, Aplastic/immunology , Bone Marrow/immunology , Hepatitis B/blood , Hepatitis B/immunology , Humans , Immunity, Cellular , Lymphocytes/immunology , MaleABSTRACT
Factors influencing small bowel morphology in dermatitis herpetiformis (DH) were investigated by comparing patients with DH and normal small bowel biopsies to patients with DH and abnormal small bowel biopsies. The mean age of 18 patients with morphological changes in small bowel (38 years) was significantly lower (P less than 0-001) than the mean age of nine patients with normal bowel mucosa (60 years). HLA typing confirmed the high frequency of HLA-B8 in DH (64%) but HLA-B8 was unrelated to the presence or severity of small bowel lesions. Four patients had diarrhoea with progressive weight loss or abdominal cramps subsequently responsive to gluten withdrawal. In this subgroup serum levels of IgG and IgM were significantly lower than in patients with normal small bowel mucosa. Small bowel involvement appeared to be independent of the duration and severity of skin disease, and the deposition of immunoglobulin and complement (C3) in the dermal papillae of skin adjacent to skin lesions.