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1.
J Aerosol Med Pulm Drug Deliv ; 23 Suppl 1: S1-10, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20373904

ABSTRACT

Conventional aerosol delivery systems and the availability of new technologies have led to the development of "intelligent" nebulizers such as the I-neb Adaptive Aerosol Delivery (AAD) System. Based on the AAD technology, the I-neb AAD System has been designed to continuously adapt to changes in the patient's breathing pattern, and to pulse aerosol only during the inspiratory part of the breathing cycle. This eliminates waste of aerosol during exhalation, and creates a foundation for precise aerosol (dose) delivery. To facilitate the delivery of precise metered doses of aerosol to the patient, a unique metering chamber design has been developed. Through the vibrating mesh technology, the metering chamber design, and the AAD Disc function, the aerosol output rate and metered (delivered) dose can be tailored to the demands of the specific drug to be delivered. In the I-neb AAD System, aerosol delivery is guided through two algorithms, one for the Tidal Breathing Mode (TBM), and one for slow and deep inhalations, the Target Inhalation Mode (TIM). The aim of TIM is to reduce the treatment time by increasing the total inhalation time per minute, and to increase lung deposition by reducing impaction in the upper airways through slow and deep inhalations. A key feature of the AAD technology is the patient feedback mechanisms that are provided to guide the patient on delivery performance. These feedback signals, which include visual, audible, and tactile forms, are configured in a feedback cascade that leads to a high level of compliance with the use of the I-neb AAD System. The I-neb Insight and the Patient Logging System facilitate a further degree of sophistication to the feedback mechanisms, by providing information on long term adherence and compliance data. These can be assessed by patients and clinicians via a Web-based delivery of information in the form of customized graphical analyses.


Subject(s)
Drug Delivery Systems/instrumentation , Nebulizers and Vaporizers/trends , Pharmaceutical Preparations/administration & dosage , Administration, Inhalation , Aerosols , Algorithms , Drug Delivery Systems/trends , Equipment Design , Humans , Medication Adherence , Respiratory Mechanics , Technology, Pharmaceutical/instrumentation , Technology, Pharmaceutical/trends , Time Factors
2.
J Aerosol Med Pulm Drug Deliv ; 23 Suppl 1: S21-7, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20373906

ABSTRACT

BACKGROUND: The telehealth service is one of the fastest growing healthcare segments. It is increasingly utilizing computer technology and telecommunication equipment to either provide continuous vital sign monitoring or facilitate patient care at home, rather than relying solely on in-person care. METHODS: We conducted a 6-week open study in nineteen patients with cystic fibrosis enrolled from three centers, to investigate patient perception of a telehealth enabled nebulizer system (Prodose Adaptive Aerosol Delivery [AAD] System), which enabled the doorstep delivery of repeat medication. RESULTS: The results showed that patient confidence in the device and perception of ease of use was high with no significant change between the start and end of the trial. Views on the home delivery of medication were split between 'great' and 'inconvenient.' However, if the delivery system had been more flexible and delivered all the patients' drugs, the majority of patients would have had their medication delivered in this way. CONCLUSIONS: The trial showed that it was possible to build telehealth technology into an advanced nebulizer system, and that patient acceptance of the technology was unlikely to be a barrier to the adoption of such a telehealth system.


Subject(s)
Drug Delivery Systems/instrumentation , Home Care Services/organization & administration , Patient Acceptance of Health Care/statistics & numerical data , Telemedicine/methods , Administration, Inhalation , Adult , Aerosols , Child , Cystic Fibrosis/drug therapy , Female , Humans , Male , Nebulizers and Vaporizers , Pharmaceutical Preparations/administration & dosage , Surveys and Questionnaires , Technology, Pharmaceutical/instrumentation , Telemedicine/instrumentation
3.
J Aerosol Med Pulm Drug Deliv ; 23 Suppl 1: S45-54, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20373909

ABSTRACT

BACKGROUND: The time requirements for multiple daily nebulizer treatments are important impediments to the quality of life for most patients with cystic fibrosis (CF). The I-neb Adaptive Aerosol Delivery (AAD) System can be used with a new mode of breathing during inhalation of aerosol, the Target Inhalation Mode (TIM). As a function of the TIM algorithm, the patient is guided to a slow and deep inhalation, which can result in shorter treatment times. METHODS: This study was conducted as a 3-month patient handling study of the I-neb AAD System in 42 patients with CF aged 12-57 years. The I-neb AAD System was supplied in both the standard Tidal Breathing Mode (TBM), and in TIM. Patients were trained to use the I-neb AAD System in TIM for the delivery of all their inhaled medications, but if they were not comfortable with the TIM maneuver they could change to the TBM maneuver. The primary variables were compliance with the correct use of the I-neb AAD System, and treatment times. The secondary variables were based on study questionnaires at the end of the study and covered ease of use, patient confidence, and patient satisfaction with the I-neb AAD System. RESULTS: There were a total of 10,240 complete treatments and of these, 8979 (88%) were in TIM. Compliance with the correct use of the I-neb AAD System was 97.6%. The mean treatment time for complete treatments in TIM was 4.20 min, compared with 6.83 min when using the I-neb AAD System in TBM. The responses to the questionnaires indicated that over 77% of the patients found the I-neb AAD System in TIM to be either: very easy, easy, or acceptable to use. CONCLUSIONS: The results demonstrated that by using the I-neb AAD System in TIM, a 40-50% reduction of nebulizer treatment times, and a high level of compliance could be achieved. The results also showed that the patients found the I-neb AAD System easy to use.


Subject(s)
Drug Delivery Systems/instrumentation , Nebulizers and Vaporizers , Pharmaceutical Preparations/administration & dosage , Respiratory Mechanics , Adolescent , Adult , Algorithms , Child , Cystic Fibrosis/drug therapy , Humans , Medication Adherence , Middle Aged , Patient Acceptance of Health Care/statistics & numerical data , Patient Satisfaction , Surveys and Questionnaires , Time Factors , Young Adult
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