ABSTRACT
Comprehensive clinical, biochemical, and electrophysiologic examinations of 250 glossalgia patients have revealed disintegration of supra-segmentary vegetative formations: increased activity of sympathoadrenal and serotonin systems, depressed kallikrein-kinin system, changed level of salivary electrolytes, reduced blood supply to the facial and oral tissues and decreased sensitivity of these tissues. Based on these findings, the authors suggest a scheme of glossalgia pathogenesis, with disorders in the autonomic nervous system underlying the development of the condition. Correction of the detected shifts contributes to a more effective therapy of glossalgia.
Subject(s)
Autonomic Nervous System/physiopathology , Glossalgia/etiology , Adrenal Glands/physiopathology , Adult , Aged , Catecholamines/urine , Electrophysiology , Glossalgia/physiopathology , Humans , Lipids/blood , Middle Aged , Serotonin/blood , Sympathetic Nervous System/physiopathologySubject(s)
Autonomic Nervous System/physiopathology , Glossalgia/physiopathology , Salivary Glands/physiopathology , Aged , Female , Humans , Male , Middle AgedSubject(s)
Face/physiopathology , Glossalgia/physiopathology , Mouth/physiopathology , Sensation/physiology , Arteriosclerosis/physiopathology , Body Temperature , Chronic Disease , Gastritis/physiopathology , Glossalgia/etiology , Hemodynamics , Humans , Hypertension/physiopathology , Taste/physiologySubject(s)
Glossalgia/etiology , Lipids/blood , Aged , Chronic Disease , Female , Glossalgia/blood , Humans , Male , Middle Aged , Paresthesia/blood , Paresthesia/etiologySubject(s)
Glossalgia/urine , Hydroxyindoleacetic Acid/urine , Adult , Aged , Circadian Rhythm , Female , Humans , Male , Middle Aged , Serotonin/metabolism , SyndromeSubject(s)
Esterases/blood , Glossalgia/blood , Kallikreins/antagonists & inhibitors , Kallikreins/blood , Prekallikrein/blood , Adult , Aged , Female , Humans , Male , Middle Aged , SyndromeSubject(s)
Catecholamines/urine , Glossalgia/urine , Adult , Aged , Female , Glossalgia/etiology , Humans , Male , Middle Aged , SyndromeSubject(s)
Carotid Arteries/physiopathology , Glossalgia/physiopathology , Adult , Aged , Female , Humans , Male , Middle Aged , Plethysmography, Impedance , Vascular ResistanceABSTRACT
Under observation there were 78 patients aged 41 to 70 years suffering from the glossalgia syndrome, as well as 25 clinically healthy subjects. An activation of the sympathoadrenal system was revealed in the patients. This was ascertained on the basis of the data on vanillylmandelic acid excretion with the urine. The excretion of that acid is known to be dependent on the intensity of the paraesthesias, the duration of the ailment and the character of concurrent visceral diseases. The results obtained are regarded as evidences of the participation of the vegetative nervous system in the mechanism of the glossalgia syndrome development.