ABSTRACT
We report the inscription of fibre Bragg gratings in non-sensitised SMF 28 and HI 980 fibre by exposure to VUV F2 laser radiation at 157 nm. The modulated effective refractive index change Deltan(eff) deduced from the shift in the grating reflection peaks was Deltan(eff) = 2.8x10(-4) and 1.7x10(-4) in SMF 28 and HI 980 fibre respectively. The possible influence of non-uniformity of core exposure and VUV cladding absorption loss on these results is discussed.
Subject(s)
Fiber Optic Technology/instrumentation , Lasers , Refractometry/instrumentation , Equipment Design , Equipment Failure Analysis , Ultraviolet RaysABSTRACT
A femtosecond laser delivering pulses of wavelength 800nm and 124fs duration at rates of 1kHz has been used to investigate the two-photon excited fluorescence in the photosensitizer m-THPC. The scaling of fluorescence amplitude with laser power and fluorescence sidelight imaging are found to support a predominantly two-photon excitation mechanism. A value for the two-photon cross-section of δ=1.8×10(-57)m(4)s is derived by comparing the fluorescence signals excited by wavelengths of 800 and 400nm. Preliminary results demonstrating the two-photon induced PDT activity of m-THPC in an epithelial cell line are also reported.
ABSTRACT
We analyze statistical fluctuations in the pulse-to-pulse spatial fluence distribution of a highly multimode F2 laser beam and the influence that coherence effects have on the attainable smoothness of an ablated surface. The magnitude of fluctuations is predicted to be a few percent, with associated roughness increasing as m1/2, where m is the number of ablation pulses. By use of a white-light optical interferometer, measurements have been made of roughness induced on N-BK7 glass surfaces ablated with a 157-nm laser, and reasonable agreement with predictions based on this roughening mechanism has been found.
ABSTRACT
In this study, we report the effect of the local photosensitizer concentration upon the dynamics of the singlet oxygen-mediated photobleaching, within formalin-fixed keratinocytes. Although the cells were incubated at a single mTHPC dose, cell-to-cell variations in concentration were defined within the perinuclear region by differences in the initial amplitude of the laser-induced fluorescence emission, located around 652nm. At a fixed laser fluence-rate, it was found that the photobleaching, when plotted as a function of delivered light dose, proceeded more rapidly at higher drug concentration. The mTHPC spectral emission profile is shown to be approximately Lorentzian and remains unchanged as the photobleaching proceeds. This indicates that there is no perturbation of the detected signal due to the inner-filter effect.
ABSTRACT
High-frequency (~160 MHz) large-amplitude acoustic waves have been generated by irradiating a thin polymer film with a spontaneously mode-locked TEA (transversely-excited atmosphere) CO(2) laser and detected using a wide-bandwidth piezoelectric polymer transducer. This approach uses a simple and commonly available infrared laser, does not require special coatings to be deposited on the acoustic generating surface, and is inherently simple in its design and operation.
ABSTRACT
Wide bandwidth piezoelectric transducers made of thin (9 microns) polyvinylidene fluoride film have been used to make time-resolved measurements of the stress-wave generated by far-ultraviolet (193 nm) laser ablation in corneal tissue in vitro. At high fluence (approximately 250 mJ/cm2), ablation commences within 10 ns (+/- 5 ns) of the laser pulse and generates short acoustic impulses (approximately 30 ns). The time profile of the ablation, when coupled to the energy requirements for ablation from earlier work, allows the estimation of a temperature and a half-life for the thermal decomposition of the collagen in cornea. These values do not support a photothermal mechanism for the ablation under the experimental conditions.
