1.
Bull Exp Biol Med
; 129(5): 445-8, 2000 May.
Article
in English
| MEDLINE
| ID: mdl-10977946
ABSTRACT
The effects of anticancer drugs whose action is mediated by different mechanisms on activity of bone marrow fibroblasts and their role in the regulation of granulocytopoiesis recovery after cytostatic treatment were studied. The antimetabolite 5-fluorouracil strongly suppressed, while the anthracycline antibiotic adriamycin and the alkylating agent cyclophosphamide stimulated function of stromal cells. This largely accounted for different dynamics of recovery of the bone marrow neutrophil lineage.