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Thromb Res ; 52(2): 79-85, 1988 Oct 15.
Article in English | MEDLINE | ID: mdl-3194893

ABSTRACT

The thrombin generation test using thromboplastin reagent and synthetic substrate for thrombin and determination of factors II, X and VII using chromogenic substrates were applied to bovine and human plasma from objects with liver disease. The liver damage was accompanied with a lowering of the concentration of at least one factor of the extrinsic pathway of prothrombin activation. Use of some of these methods for laboratory diagnosis of liver damage is proposed.


Subject(s)
Factor VII/metabolism , Factor X/metabolism , Liver Diseases/blood , Prothrombin/metabolism , Animals , Blood Coagulation Tests , Cattle , Factor Xa , Humans , Liver Diseases/pathology , Serine Endopeptidases/metabolism
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