[Beta-lipotropin and beta-endorphin in compensation mechanisms of function after damage of the lateral hypothalamus]. / Beta-lipotropin i beta-éndorfin v mekahnizmakh kompensatsii funktsii posle razrusheniia lateral'nogo gipotalamusa.

Possibility of restoration of food intake and other related functions impaired after lesion of lateral hypothalamus was studied on 45 male albino non-strain rats divided into 3 groups with 15 per each. Neuropeptides beta-lipotropin (beta-LPT) and its derivative beta-endorphin were used as compensation factors. The parameters recorded were: volume of food and water intake, diuresis, body weight and temperature, frequencies of rest periods, comforting forms of behavior and orienting-exploratory activity. The results revealed that lesion of lateral hypothalamus resulted in the formation of specific central and peripheral syndrome responsible for the impairment of food intake and other related functions. Intracerebroventricular injections of beta-LPT and beta-endorphin facilitated compensation of impaired functions caused by lesion of lateral hypothalamus. The data were analyzed on the basis of the systems approach to the organism's physiological functions.

[Beta-lipotropin and beta-endorphin in the hypothalamic syndrome]. / Beta-lipotropin i beta-éndorfin pri gipotalamicheskom sindrome.

Experiments were conducted on 90 non-strain male albino rats to study the possibility of compensating food intake and the functions related to its activity in disturbances caused by damage to the arcuate region of the hypothalamus. Neuropeptides beta-lipotropin (beta-LTP) and beta-endorphin were chosen as the compensation factors. The registered parameters were as follows: the volume of food and water intake, feeding and drinking behaviors, orientating-exploratory activity, comforting behavior, and the duration of sleep and drowsiness. It was established that destruction of the hypothalamic arcuate zone is attended by the formation of a specific syndrome including disorders of food and water intake and other forms of behavior. Intraventricular injections of beta-LPT and beta-endorphin under such conditions was conductive to the restoration of the disturbed functions and compensated for food intake and other related functions.