ABSTRACT
Investigation of the psychotropic spectrum of phenobarbital, diphenin, milontin, pufemide, sodium valproate (depakine), and diazeparn showed that, besides antagonism with the corazole and electroshock effects, all these drugs prevented to a considerable degree the kindling seizures in rats on a "tonsil swing" (chronic electroencephalographic partial epilepsy) model. The mechanism of this effect probably involves exciting amino acids. All anticonvulsants except for diazepam also restored memory in experimental animals with retrograde electroshock amnesia. The administration of diazepam, diphenin, and sodium valproate to rats with kindling convulsions led to activation of the spontaneous horizontal motions in the open-field test, which can be explained by the presence of antianxiety component in the drug action.
Subject(s)
Anticonvulsants/pharmacology , Psychotropic Drugs/pharmacology , Amnesia, Retrograde/drug therapy , Animals , Anti-Anxiety Agents/pharmacology , Convulsants/antagonists & inhibitors , Electroshock , Kindling, Neurologic , Memory/drug effects , Mice , Pentylenetetrazole/antagonists & inhibitors , Rats , Rats, Wistar , Seizures/drug therapy , Seizures/etiologyABSTRACT
Some aspects of the anxiolytic action of buspirone were investigated by differentiating fear from anxiety. Buspirone showing anxiolytic and antineurotic action in the models of anxiety and conflicting situation was demonstrated to be inactive in the model of fear of falling down from the elevated cross-shaped labyrinth. The antiamnestic effect of buspirone was revealed in the electroshock amnesia model. It is assumed that serotonin receptors are possibly responsible both for the anxiety and for memory processes.
Subject(s)
Buspirone/pharmacology , Animals , Anxiety/drug therapy , Buspirone/therapeutic use , Conditioning, Classical/drug effects , Diazepam/pharmacology , Disease Models, Animal , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Escape Reaction/drug effects , Fear/drug effects , Male , Memory/drug effects , Mice , Rats , Sulpiride/pharmacologyABSTRACT
A model has been developed for screening atypical tranquilizers, which is based on the intrinsic property of mice and rats to avoid the brightly lit part of a chamber and on the effect of "optic precipice". The model enables one not only to select anxiolytic agents, but to differentiate them as atypical and classical tranquilizers.
