[Activity of antioxidant protection enzymes and content of lipid peroxidation products in blood serum and cerebrospinal fluid in patients with ischemic brain disease]. / Aktivnost' fermentov antiokislitel'noi zashchity i soderzhanie produktov perekisnogo okisleneniia lipidov v syvorotke krovi i tserebrospinal'noi zhidkosti bol'nykh ishemicheskoi bolezniu mozga.

Activity of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase as well as content of diene conjugates and malonic dialdehyde were studied in blood serum and cerebrospinal fluid of patients with transitory ischemia, small ischemic insult, ischemic insult of middle severity and with severe ischemic insult without lethality within 1-2, 7-8 and 14-15 days of diseases. Content of lipid peroxidation products and activity of antioxidant enzymes were decreased in the biological fluids studied in all the forms of brain circulation impairments within early periods of pathology. These patterns tend to normalization within 14-15 days. The rate of biochemical alterations corresponded highly to severity of impairments developed and these patterns may be used for diagnostic and prognostic purposes.

[Effect of alpha-tocopherol and selenium on the activity of antioxidant enzymes and level of lipid peroxidation products in erythrocytes of patients with cerebral ischemia]. / Vliianie alpha-tokoferola i selena na aktivnost' antioksidantnykh fermentov i soderzhanie produktov perekisnogo okisleniia lipidov v éritrotsitakh bol'nykh ishemicheskoi bolezn'iu mozga.

Antioxidant drugs: alpha-tocopherol acetate and "Selenium" (Finland) were used in treatment of patients with small ischemic insult and middle severity ischemic insult; the state of endogenous antioxidant system and intensity of lipid peroxidation were studied in erythrocytes within various periods of diseases. Content of diene conjugates and malonic dialdehyde was decreased, while activity of superoxide dismutase, catalase, glutathione peroxidase and reductase was increased after administration of both these antioxidants during treatment of the brain circulation impairments. Simultaneous use of the drugs caused the highest effect which occurred due to their influence on various pathways of the endogenous antioxidant system.