[Heart rate variability in patients with diffuse toxic goiter].

Functional state of the vegetative nervous system of 18 patients with first time diagnosed moderate thyrotoxicosis has been analyzed. Vegetative tonus, vegetative reactivity and vegetative activity during daily activity was assessed based on heart rate variability.

[Changes in autonomic regulation in patients with multiple sclerosis during hyperbaric oxygenation]. / Izmeneniia vegetativnoi reguliatsii u bol'nykh rasseiannym sklerozom vo vremia giperbaricheskoi oksigenatsii.

Our objective in this study was to determine phase transitions of bodily vegetative reactivity in different baseline functional states in patients with multiple sclerosis (MS) during the stages of the hyperbaric oxygen (HBO) procedures. The developed technology of appraisal of vegetative reactivity in therapeutic hyperoxia enables bodily adaptive reactions to be objectively determined in curative hyperoxia on a present-day informative and scientific level. Monitoring of vegetative changes during the course of barotherapy permits securing an individual HBO dosing consistent with the level of resistance to hyperoxia.

[The dynamics of the autonomic indices in participants in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station at the stages of therapeutic hyperoxia]. / Dinamika vegetativnykh pokazatelei u uchasnikov likvidatsii posledstvii avarii na ChAES na étapakh lechebnoi giperoksii.

Time-related course was studied of vegetative indicators during the hyperbaric oxygenation (HBO) sessions in 36 liquidators of the effects of the Chernobyl Nuclear Power Plant breakdown, who suffered from early forms of cerebrovascular insufficiency. Shown for the first time in therapeutic hyperoxia in the liquidators are features of the time-related course of vegetative regulation. Significant group particularities of changes in vegetative regulation have been stated, that suggest a different approach to the tactics of HBO employment. Those patients experiencing a higher tenseness of vegetative regulation demonstrated antecedents of toxic action of oxygen at minute 35 to 40 HBO. The employed vegetative indicators monitoring technology allowed the establishment of individualized hyperoxia doses, with the early signs of oxygen overdose being revealed in real time.

[The pathogenetic role of circulating immune complexes in multiple sclerosis]. / Patogeneticheskaia rol' tsirkuliruiushchikh immunnykh kompleksov pri rasseiannom skleroze.

CIC in multiple sclerosis were assessed qualitatively and quantitatively. CIC changes in response to hormone therapy were also studied. It was found that in multiple sclerosis CIC contain antibodies to brain tissue, thymus, hepatic lipoprotein, adrenal cortex, leukocytes, gastric mucosa. A positive response of CIC levels to hormone treatment is stated.

[The significance of a natural inhibitory factor in the pathogenesis of disseminated sclerosis]. / Znachenie estestvennogo ingibiruiushchego faktora v patogeneze rasseiannogo skleroza.

Results indicate that during exacerbation patients with multiple sclerosis showed marked T-lymphopenia, decrease of histamine-sensitive RFC while active RFC exhibited varied changes of their content; increase of the circulating immune complexes, absence or low NIF level. The effect of corticosteroid therapy on the NIF dynamics was evaluated and its level was found to be increased due to hormone treatment. Prednisolone furthers T-cell immunodeficiency and also reduces the intensity of autoimmune reactions in multiple sclerosis. NIF may be used as a prognostic criterion for the evaluation of completeness and duration of the remission. Prolonged functioning of NIF leads to suppression of the patient's immune reactivity requiring immunocorrection.

[The role of autoimmune reactions in the development of disseminated sclerosis]. / Rol' nekotorykh autoimmunnykh reaktsii v razvitii rasseiannogo skleroza.

The immune status was investigated in 97 patients with multiple sclerosis. Patients of this group showed marked changes at the cellular lever of the immune system. T-lymphocytopenia was accompanied by a dysbalance of the main correlative cells according to a relatively hyposuppressor variant of immune deficit with formation of circulating immune complexes and thermodependent lymphocytotoxic autoantibodies.

[Indicators of cellular immunity in patients with multiple sclerosis]. / Pokazateli kletochnogo immuniteta u bol'nykh rasseiannym sklerozom.

As many as 111 patients with multiple sclerosis were subjected to clinical and functional examinations twice: on admission to the hospital and after immunocorrective therapy. The patients were discovered to have alterations in cellular immunity. During exacerbation, there was a decline of suppressors and a rise of the content of B lymphocytes. The immunocorrective therapy led to immunodeficiency stabilization.

[Pathogenesis of retrobulbar neuritis]. / O patogeneze retrobul'barnogo nevrita.

Biological fluids from 146 patients with retrobulbar neuritis were examined for the biochemical, immunochemical and immunologic characteristics that mirror destructive processes in myelin and changes in the system of the cholinoglycine cycle which is one of the stages of the synthesis of myelin in the oligodendrocyte. In the majority of observations, the changes in these reactions of different directions and of varying intensity were revealed. Based on the data obtained the conclusion is made that part of the patients with retrobulbar neuritis may be attributed to multiple sclerosis since according to the laboratory findings, the demyelinating process occurring in them goes beyond optic nerves. Besides, it has been shown with special reference to retrobulbar neuritis that the primary affect, possibly of the viral nature, is likely to be localized in the oligodendrocyte, with myelin being involved in the process for the second time.

[Disorders of formaldehyde metabolism and its metabolic precursors in patients with multiple sclerosis]. / Narushenie obmena formal'degida i ego metabolicheskikh predshestvennikov u bol'nykh rasseiannym sklerozom.

Blood serum and cerebrospinal fluid were studied in 90 patients with multiple sclerosis. Patients showed substantially elevated levels of formaldehyde and N-methyl amino acids as related to control subjects. These metabolites' concentration was also higher in those patients with prevailing cerebellar signs and progressive course of the disease or in exacerbations of remission course compared with the cases of prevailing pyramidal structures involvement and benign course with long-lasting remissions. Glycine administration resulted in reduced blood levels of formaldehyde. Its role in the pathogenesis of multiple sclerosis is discussed.