[Use of antibiotics and their combinations with immunomodulators in treatment of experimental salmonellosis in albino rats]. / Primenenie antibiotikov i ikh sochetanii s immunomoduliatorami s lechebnoi tsel'iu pri éksperimental'nom sal'monelleze u belykh krys.

Efficacy of the combined therapy of experimental salmonellosis was studied on albino rats with using ampicillin, gentamicin, tetracycline and immunomodulators such as levamisole and quadevite. The influence of the combined chemoimmunotherapy on the indices of the nonspecific resistance of the animals i.e. the titers of lysozyme and beta-lysines, the complement activity and the blood serum bactericidal index was investigated. An increase in the survival of the animals exposed to the combinations of tetracycline with levamisole and quadevite by comparison with the animal survival after the monotherapy was revealed. The combinations of gentamicin with quadevite and tetracycline with the immunomodulators significantly increased the blood serum bactericidal index.

[Effect of combined preventive use of quadevit with antibiotics on the survival and humoral immune response in experimental studies]. / Vliianie kombinirovannogo profilakticheskogo primeneniia kvadevita s antibiotikami na vyzhivaemost' i gumoral'nyi immunnyi otvet v éksperimente.

An attempt to correct with quadevit immunodepression due to prophylactic administration of benzylpenicillin and gentamicin for 6 days provided positive results. There was a significant increase in the quantities of Ig 19S and Ig 7S after the animal immunization with the bacterial antigen, an increase in the number of the AFCs in the spleen of the albino mice in response to administration of sheep erythrocytes and an increase in the survival rate of the animals with salmonellosis. The simultaneous use of quadevit with cefamezine and erythromycin did not lower the unfavourable influence of the antibiotics on the immune status of the animals.

[The significance of eosinophilia in diagnosing rheumatism activity]. / Znachenie éozinofilii v raspoznavanii aktivnosti revmatizma.

Increases of the level of eosinophils in patients with rheumatism depends on the character of the disease course. In patients suffering of latent rheumatism with a subminimal activity, no increased number of circulating eosinophils is observed. It was established that patients with active rheumatism showed an increased subpopulation of eosinophils characterized by low density.

[Immunomodulating effect of levamisole in antibiotic therapy]. / Immunomoduliruiushchee vliianie levamizola v usloviiakh antibiotikoterapii.

The use of ampicillin, benzylpenicillin, gentamicin, erythromycin, cefamezine or cephaloridine in combination with levamisole aimed at increasing their efficacy and correcting the adverse reactions was studied. Immunological activity of the antibiotics was comparatively characterized by using standard methods. It was shown that the character of the antibiotic effect on the basic factors of nonspecific resistance and immunity was heterogeneous. Schemes for using the antibiotics in combination with levamisole for correcting the detected disorders in the immunity status of the experimental animals were developed.

[Effect of Pseudomonas aeruginosa exotoxin on blood biochemical indices in an experiment]. / Vliianie ékzotoksina Pseudomonas aeruginosa na nekotorye biokhimicheskie pokazateli krovi v éksperimente.

Some problems connected with the pathogenic action of P. aeruginosa exotoxin under experimental conditions have been studied. The study has revealed that in the process of P. aeruginosa intoxication the development of hypoproteinemia, an increase in the activity of aminotransferases, lactate dehydrogenase and its isoforms occurs in the body. The characteristic features of the process are phasic changes in the activity of ceruloplasmin and in the amount of sulfhydryl groups.

[Mechanism of action of Pseudomonas aeruginosa exotoxin on the macroorganism (experimental studies)]. / Mekhanizm deistviia ékzotoksina Pseudomonas aeruginosa na makroorganizm (éksperimental'nye issledovaniia).

Some problems of the pathogenic action of P. aeruginosa exotoxin on the body have been experimentally studied. Under the conditions of intoxication produced by P. aeruginosa exotoxin pronounced functional disturbances in the main parameters of central hemodynamics and changes in the coagulation properties of the blood and in the free-radical peroxidation of lipids have been found to occur. The manifestation of pathological changes has been shown to have certain specific features in different organs and to depend on the time elapsed after the introduction of exotoxin into the animals.

[Virulence and toxigenicity of Pseudomonas aeruginosa cultures of various origins]. / Virulentnost' i toksigennost' kul'tur Pseudomonas aeruginosa raznogo proiskhozhdeniia.

The virulence and toxigenicity of newly isolated P. aeruginosa strains have been studied in experiments on white mice. These biological properties have been shown to be most pronounced in P. aeruginosa strains isolated from proteins, sometimes greatly exceeding those in strains isolated from healthy persons and the environment. Virulence and the factors which determine it are definitely interrelated in microorganisms and can vary, depending on the conditions of their habitat.

[Possible connection between the virulence of Pseudomonas aeruginosa bacteria and their ultrastructural characteristics]. / O vozmozhnoi sviazi mezhdu virulentnost'iu bakterii Pseudomonas aeruginosa i nekotorymi osobennostiami ikh ul'trastruktury.

The results of the electron-microscopic study of P. aeruginosa isolated from patients with surgical inflammatory purulent processes and from the environment (water, soil) are presented. The morphological features of the subcellular structure of virulent and non-virulent P. aeruginosa strains, as well as their adaptation properties, appearing under unfavorable conditions have been established.

[The effect of Pseudomonas aeruginosa exotoxin on various nonspecific factors of immunologic reactivity in an experiment]. / Vliianie ékzotoksina Pseudomonas aeruginosa na nekotorye nespetsificheskie faktory immunologicheskoi reaktivnosti organizma v éksperimente.

The main characteristics of the nonspecific responsiveness of the body have been studied on the model of acute P. aeruginosa intoxication. An increase in phagocytic and lysozyme activity and in the bactericidal properties of blood serum have been shown to occur during the first 6 hours after the introduction of P. aeruginosa exotoxin. The titer of complement and beta-lysin activity decrease. At a later period of observations a sharp drop in all the characteristics under study (except lysozyme activity) occurs.

[Experimental effect of Pseudomonas aeruginosa exotoxin on the permeability of the microcirculatory bed of organs and tissues]. / Vliianie ékzotoksina sinegnoinoi palochki na pronitsaemost' mikrotsirkuliatornogo rusla organov i tkanei v éksperimente.

Experimental study with the use of 131I-albumin has revealed changes in the micro-circulatory blood channel and in the permeability of the blood vessels for albumin under the conditions of pyocyanic intoxication caused partly by purified P. aeruginosa exotoxin.