ABSTRACT
We studied the effects of 30-day injections of sulpyride and treatment with Prostatilen on the development of prostatic hyperplasia and LPO in rats. Sulpyride induced proliferation of lateral lobes, increased the content of lipid hydroperoxides and glutathione peroxidase activity in the gland; in the blood this preparation increased lipid hydroperoxide concentration and decreased glutathione peroxidase and total antioxidant activity. Prostatilen prevented the development of hyperplasia and normalized the prooxidant-antioxidant balance in tissues, except total antioxidant activity of the blood.
Subject(s)
Peptides/therapeutic use , Prostatic Hyperplasia/blood , Prostatic Hyperplasia/metabolism , Prostatic Hyperplasia/prevention & control , Animals , Glutathione Peroxidase/blood , Glutathione Peroxidase/metabolism , Lipid Peroxides/blood , Lipid Peroxides/metabolism , Male , Oxidation-Reduction , Prostatic Hyperplasia/chemically induced , Prostatic Hyperplasia/enzymology , Rats , Rats, Inbred Strains , SulpirideABSTRACT
We studied the effect of transplantation of fetal liver cells and postnuclear cytoplasmic fraction from human fetal soft tissues on the prooxidant-antioxidant equilibrium in the liver and blood of rats after partial hepatectomy. The preparations increased antioxidant activity and decreased the intensity of lipid peroxidation, which probably contributes to their therapeutic effects.
