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1.
Interv Neuroradiol ; 24(2): 225-228, 2018 Apr.
Article in English | MEDLINE | ID: mdl-28994621

ABSTRACT

Vertebral artery origin anomalies are typically incidental findings during angiography. We present an extremely rare variant in which the right vertebral artery has a double origin from the right subclavian artery and right common carotid artery in association with an aberrant right subclavian artery, which has never been reported before.


Subject(s)
Aneurysm/diagnostic imaging , Cardiovascular Abnormalities/diagnostic imaging , Carotid Artery, Common/abnormalities , Cerebellar Diseases/diagnostic imaging , Cerebellar Diseases/surgery , Hematoma/diagnostic imaging , Hematoma/surgery , Subclavian Artery/abnormalities , Vertebral Artery/abnormalities , Adolescent , Angiography, Digital Subtraction , Cerebral Angiography , Female , Humans , Subclavian Artery/diagnostic imaging , Tomography, X-Ray Computed
3.
Int Urol Nephrol ; 41(3): 571-7, 2009.
Article in English | MEDLINE | ID: mdl-18810651

ABSTRACT

BACKGROUND: To evaluate the risk factors for invasive bladder cancer and to develop a predictive model for the improvement of individual comprehensive therapy for invasive bladder cancers. MATERIALS AND METHODS: The records of 356 patients with invasive bladder cancer, operated on at three Chinese medical institutes, were reviewed. The Cox proportional hazards regression model was used to assess the clinical and pathological variables affecting disease-free survival (DFS). The regression coefficients determined by Cox regression analysis were used to construct a predictive index (PI). PI was used to categorize the patients into different risk groups. Kaplan-Meier survival curves followed with log-rank test were plotted to compare the difference. RESULTS: Tumor configuration (RR = 1.60, P = 0.01), multiplicity (RR = 1.41, P = 0.04), histological subtype (RR = 2.13, P < 0.01), tumor stage (RR = 2.50, P < 0.01), tumor grade (RR = 2.35, P < 0.01), node status (RR = 2.48, P < 0.01), and neoadjuvant chemotherapy (RR = 0.46, P = 0.02), had independent prognostic significance for DFS. PI = 0.47 x (configuration) + 0.34 x (multiplicity) + 0.76 x (tumor histological subtype) + 0.92 x (stage) + 0.86 x (grade) + 0.91 x (node status) - 0.79 x (neoadjuvant chemotherapy). The range of PI was -0.32 to 6.52, which was equally divided into three risk groups with significant differences on Kaplan-Meier curves and a log-rank test (P < 0.01). Meanwhile, the patient's probability of survival could be calculated by PI. CONCLUSIONS: Seven factors (tumor configuration, multiplicity, histological subtype, tumor stage, tumor grade, node status, neoadjuvant chemotherapy) affect the prognosis after radical cystectomy (RC) for invasive bladder cancer. PI can be used to optimize the individual comprehensive therapy. Given fewer perioperative complications, fast recovery from surgery and relatively satisfactory quality of life, ureterocutaneostomy, and ileal conduit are suitable for the patients with short expected life spans.


Subject(s)
Urinary Bladder Neoplasms/mortality , Urinary Bladder Neoplasms/therapy , Adult , Aged , Aged, 80 and over , Chemotherapy, Adjuvant , China , Cystectomy , Female , Humans , Male , Middle Aged , Neoplasm Invasiveness , Risk Assessment , Survival Rate , Urinary Bladder Neoplasms/pathology
4.
Urol Oncol ; 27(4): 400-6, 2009.
Article in English | MEDLINE | ID: mdl-18818109

ABSTRACT

This study was undertaken to identify differences in protein expression profiles between superficial bladder transitional cell carcinoma (BTCC) and normal urothelial cells. We used laser capture microdissection (LCM) to harvest purified cells, and used two-dimensional liquid chromatography (2D-LC) followed by electrospray ionization-tandem mass spectrometry (ESI-MS/MS) to separate and identify the peptide mixture. A total of 440/438 proteins commonly appeared in 4 paired specimens. Multi-step bioinformatic procedures were used for the analysis of identified proteins; 175/179 of the 293/287 proteins that were specific expressed in tumor/normal cells own gene ontology (GO) biological process annotation. Compared with the entire list of the international protein index (IPI), there are 52/46 GO terms exhibited as enriched and 6/10 exhibited as depleted, respectively. Significantly altered pathways between tumor and normal cells mainly include oxidative phosphorylation, focal adhesion, etc. Finally, descriptive statistics show that the shotgun proteomics strategy has practice directive significance for biomarker discovery by two-dimensional electrophoresis (2-DE) technology.


Subject(s)
Carcinoma, Transitional Cell/drug therapy , Carcinoma, Transitional Cell/metabolism , Gene Expression Profiling , Gene Expression Regulation, Neoplastic , Urinary Bladder Neoplasms/drug therapy , Urinary Bladder Neoplasms/metabolism , Urothelium/pathology , Chromatography, Liquid/methods , Computational Biology/methods , Electrophoresis, Gel, Two-Dimensional , Humans , Mass Spectrometry/methods , Models, Genetic , Phosphorylation , Proteomics/methods , Spectrometry, Mass, Electrospray Ionization/methods
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