1.
Serum macroglobulin stimulation of the proliferation and differentiation of granulocytic precursors.
Trans Am Microsc Soc
; 94(3): 375-83, 1975 Jul.
Article
in English
| MEDLINE
| ID: mdl-1162841
Subject(s)
Granulocytes , Hematopoiesis/drug effects , Leukocytes , Macroglobulins/pharmacology , Animals , Cell Differentiation , Cell Division , Male , Rats , Spleen
2.
J Am Geriatr Soc
; 23(4): 175-9, 1975 Apr.
Article
in English
| MEDLINE
| ID: mdl-46873
ABSTRACT
This investigation was undertaken to determine whether there is a decrease of granulopoietic activity in subjects of the geriatric age group. Colony-stimulating factor (CSF) is an alpha glycoprotein which causes proliferation of granulocytes in vitro. A study was made of the variation in the level of CSF with age and the state of health in 78 subjects. They were classified into two groups-young (ages 22-60) and old (ages 70-94). The state of health was classified as normal, acute disease, or chronic disease. The results showed that serum CSF does vary with age and health. The CSF levels were higher in the young than in the old. For both age groups, the CSF levels were elevated in acute disease, and subnormal in chronic disease.
Subject(s)
Aging , Bone Marrow Cells , Bone Marrow/immunology , Granulocytes , Leukocytes , Acute Disease , Adult , Aged , Alpha-Globulins/analysis , Beta-Globulins/analysis , Cell Division , Chronic Disease , Clone Cells , Glycoproteins/blood , Humans , Middle Aged
3.
Trans Am Microsc Soc
; 91(3): 299-310, 1972 Jul.
Article
in English
| MEDLINE
| ID: mdl-4557418
Subject(s)
Blood Proteins/analysis , Bone Marrow Cells , Bone Marrow/metabolism , Hematopoiesis , Animals , Blood Cell Count , Bone Marrow Transplantation , Cell Count , Chromatography, Gel , Hematopoietic Stem Cells/metabolism , Male , Radiation Effects , Rats , Rats, Inbred Strains , Spleen/radiation effects , Thymidine/metabolism , Transplantation, Homologous , Tritium
4.
J Am Geriatr Soc
; 20(4): 174-7, 1972 Apr.
Article
in English
| MEDLINE
| ID: mdl-5016634
