1.
Mol Biol Rep
; 3(6): 443-9, 1977 Dec.
Article
in English
| MEDLINE
| ID: mdl-339057
ABSTRACT
We have studied the effects on the yeast mitochondrial genome of four analogues of ethidium bromide, in which the phenyl moieyt has been replaced by linear alkyl chains of lengths varying from seven to fifteen carbon atoms. These analogues are more efficient than ethidium bromide in inducing petite mutants in Saccharomyces cervisiae. The drugs also cause a loss of mtDNA from the cells in vivo; however these analogues are in fact less effective inhibitors of mitochondrial DNA replication per se, as shown by direct in vitro studies. It is concluded that these analogues are more efficient than ethidium bromide in causing the fragmentation of mitochondrial DNA in S. cervisiae.
Subject(s)
DNA, Mitochondrial/antagonists & inhibitors , Ethidium/analogs & derivatives , Mutagens , Ethidium/pharmacology , Saccharomyces cerevisiae/drug effects , Saccharomyces cerevisiae/genetics
2.
J Chem Soc Perkin 1
; 19: 1653-69, 1966.
Article
in English
| MEDLINE
| ID: mdl-5950461
3.
Tetrahedron Lett
; (4): 369-72, 1966 Jan.
Article
in English
| MEDLINE
| ID: mdl-5905315