We know how to prescribe natalizumab for multiple sclerosis, but do we know how to withdraw it?

Natalizumab is a potent immunosuppressive monoclonal antibody used for the treatment of multiple sclerosis (MS). While definite guidelines for the safety of natalizumab prescriptions are available in all countries, there are no specific recommendations on how to withdraw the drug if the need arises. There are reports describing MS complications after natalizumab infusions were stopped. Most neurologists seem to stop natalizumab treatment according to their idea on how to best carry out the withdrawal. The present study shows the very different manners in which expert neurologists from 14 MS units in Brazil stopped natalizumab in their patients. The authors concluded that pharmacovigilance on natalizumab must persist after the drug is withdrawn in order to have enough data for adequate recommendations.

"Take my water": liberation through prohibition in San Pedro Chenalhó, Chiapas, Mexico.

This article explores changing views of alcohol in San Pedro Chenalhó, a township in highland Chiapas, Mexico that has been profoundly transformed by the Zapatista democracy movement. The first part of the article provides an overview of drinking in Chenalhó in the 1970s and 1980s when alcohol was still a strong symbol of community solidarity and an important part of healing ceremonies. The second part describes the period since the Zapatista uprising, a period in which indigenous women have begun to intensify their involvement in the political affairs of their communities. In their search for autonomy and to recover pride and dignity, both women and men supporters of the Zapatista movement reject alcohol as a symbol of political and economic domination. A commentary examines the relationship between the critiques of alcohol that have developed in Chenalhó since the 1970s and political economy perspectives in alcohol studies. Both explanatory frameworks focus on the power structures in which alcohol sales and use are embedded.

Clinical features and outcomes of HIV-related cytomegalovirus pneumonia.

OBJECTIVE: To describe the characteristics and outcomes of HIV-infected patients with biopsy-proven cytomegalovirus (CMV) pneumonia. DESIGN: Retrospective study. SETTING: A 900-bed acute facility in New York City. PATIENTS: Eighteen HIV-infected patients with pathologically confirmed CMV inclusions in lung tissue without other pathogens and 36 control patients with biopsy-proven Pneumocystis carinii pneumonia (PCP) selected for comparisons by computer-generated random sequential numbers. MAIN OUTCOME MEASURES: Demographic, clinical, laboratory, radiological findings, and in-hospital mortality. RESULTS: Eighteen HIV-infected patients were found to have CMV lung infection alone. Pathologic findings were pneumonitis (n = 11); pneumonitis and pulmonary vasculitis (n = 1); and CMV inclusions alone (n = 6). All presented with respiratory symptoms (cough or dyspnea), 89% had fever, 83% had radiological abnormalities, and 56% had severe hypoxemia. The pulmonary presentation was similar except for higher lactate dehydrogenase (median, 449 versus 329 IU/l; P = 0.03) and presence of pleural effusions (33 versus 0%; P = 0.001) in CMV patients. Multivariate analysis showed that CD4 counts < or = 12 x 10(6)/l (odds ratio; 9.2; P = 0.029) and extrapulmonary CMV (odds ratio, 20.4; P = 0.039) were independently associated with CMV pneumonia. Seventeen patients received specific anti-CMV therapy for a mean of 22 +/- 13 days. In-hospital mortality was higher in patients with CMV pneumonia (odds ratio, 11.9; P = 0.002). The median time from admission to death was 31 days. CONCLUSIONS: CMV lung infection was seen in severely immunosuppressed HIV-positive patients and associated with clinical pneumonitis with high early mortality. Although the clinical features resemble PCP, the presence of extrapulmonary CMV disease should suggest the diagnosis of CMV pneumonia.

Subcarinal cavernous hemangioma: CT findings.

Cavernous hemangiomas of the mediastinum, though unusual, have typically been described in the anterior or posterior mediastinum. We report such a tumor in the subcarinal region and describe the potential contribution of CT scanning in the work-up of these rare space-occupying lesions.

Primary intrathoracic malignant mesenchymal tumors: pictorial essay.

Primary mesenchymal intrathoracic tumors are unusual. They can originate from the lung, the pleura, or the mediastinal structures. These sarcomas have protean, nonspecific imaging features. This pictorial essay illustrates a large number of these tumors, describes the plain film findings, and emphasizes the contribution of the new imaging modalities. The cross-sectional display and the high contrast resolution computed tomography (CT) and the ability to image vascular structures and chest wall with magnetic resonance (MR) allow excellent delineation of tumor extent and assessment of chest wall or vascular invasion. Early recognition of recurrence or metastases can be facilitated. In rare instances, the intrinsic characteristics of the tumor allow a specific diagnosis.

Bronchiolitis obliterans on high-resolution CT: a pattern of mosaic oligemia.

OBJECTIVE: Bronchiolitis obliterans, when not associated with organizing intraalveolar pneumonia or extensive peribronchiolar fibrosis, is often difficult to distinguish clinically and radiographically from other forms of chronic obstructive pulmonary disease. The aim of this study was to demonstrate a pattern on high-resolution CT (HRCT) that could suggest this diagnosis. MATERIALS AND METHODS: Two patients with a clinical diagnosis of bronchiolitis obliterans, moderate-to-severe obstruction on pulmonary function tests, and normal chest radiography were studied with HRCT. RESULTS: High-resolution CT of the patients with chronic bronchiolitis demonstrated a mosaic pattern of low attenuation probably corresponding to secondary lobules. CONCLUSION: We conclude that the low attenuation areas represent either air trapping or hypoxic vasoconstriction in secondary pulmonary lobules from obstruction of small airways. This pattern of mosaic oligemia was, until recently, only recognized with occlusive vascular disease and may suggest obstructive disease in the small airways.