ABSTRACT
A method for longterm tissue culture of human arterial explants is described. The explants of normal and atherosclerotic femoral arteries, removed immediately post mortem, were kept in culture for up to 14 days in a biochemically active state. Viability was checked by glucose uptake and lactate production, with daily changes of incubation media and sterility controls. Compared to the well established short term incubation systems where metabolic activity decreases progressively after 6 h, glucose uptake, lactate production and uptake of 3H-oleic acid are linear within 4-14 h. The highest incorporation of 3H-oleic acid is found in phospholipids, the lowest in cholesterol ester. But whilst activity, after the pulse label of 24 h, progressively decreases in phospholipids, it constantly increases in the cholesterol ester fraction as a consequence of the persistant cholesterol esterification.
Subject(s)
Arteries , Arteriosclerosis/pathology , Cholesterol/metabolism , Culture Techniques , Femoral Artery/metabolism , Glucose/metabolism , Humans , Lactates/metabolism , Oleic Acids/metabolism , Phospholipids/metabolism , Time FactorsABSTRACT
The "best" strategy for personality scale construction may be a utilitarian concept rather than a psychometric one. Some specific suggestions are given.
ABSTRACT
A case of an unusual combination of a metastasing bronchus cancer, a non-metastasing cancer of prostata and an excessive high level of serum-estrogen is described. This casuistic gives rise to some more general discussion of the pathogenesis and differential diagnosis of paraneoplastic endocrinopathies.
PIP: Breast cancer was discovered in a 78-year-old man, which came from a metastasizing bronchus cancer. Investigation showed a level of serum estrogen 20 times higher than normal. This was probably due to a nonmetastasizing prostate cancer, spironalactone therapy for heart trouble, paraneoplactic endocrinopathy, and the Pierre-Marie-Bamberger syndrome.
Subject(s)
Breast Neoplasms/complications , Bronchial Neoplasms/complications , Estrogens/blood , Neoplasms, Multiple Primary/diagnosis , Paraneoplastic Endocrine Syndromes/diagnosis , Prostatic Neoplasms/complications , Aged , Arrhythmias, Cardiac/complications , Bronchial Neoplasms/blood , Bronchial Neoplasms/metabolism , Carcinoma/complications , Cytoplasmic Granules , Estrogens/biosynthesis , Gynecomastia/etiology , Humans , Hypothalamus/pathology , Male , Neoplasm Metastasis , Prostatic Neoplasms/bloodSubject(s)
Menstruation Disturbances , Personality , Adolescent , Adult , Female , Humans , MMPI , Menstruation , Nursing , Premenstrual Syndrome , Psychophysiologic Disorders , Statistics as TopicSubject(s)
Mental Disorders/diagnosis , Psychiatry , Psychology, Clinical , Computers , Humans , Interprofessional Relations , Methods , Psychological TestsABSTRACT
Using Maxplane, Thurstone's Box Problem is shown to be indeterminate. Slight modifications of the data matrix eventually allow an exactly perfect solution, however. It is suggested that obtained data matrices may often not be determinate with respect to simple structure, and that prolonged experimentation may be required before it is reasonable to expect such determinacy. I.
ABSTRACT
Cross-validation of previously published findings regarding the structure of rehabilitation data yields substantial evidence that this structure is stable and quite definitive. Tentative data are presented regarding relation- ships between intelligence and personality on the one hand, and rehabilitation outcomes on the other. It appears that intelligence is more related to short- run outcomes; personality more related to long-run outcomes.
