ABSTRACT
Las personas que padecen patologías de salud mental con frecuencia sufren estigma y exclusión por parte de la sociedad. El desconocimiento y el temor a ser discriminado evita el acercamiento de las personas a los servicios de salud, provocando latencias y abandono del tratamiento. La psicoeducación es una herramienta que busca que pacientes y familias conozcan la naturaleza de la enfermedad, promoviendo la autonomía, el empoderamiento y la reintegración social. El siguiente artículo recoge evidencia en torno a esta temática, discutiendo sobre la aplicabilidad de sus resultados, la importancia de replicar métodos y sistematizar experiencias.
Mental health illness are often related with social stigma. The unknowledge and the generalization of conducts of people with mental health illness, impacts the approach to social or medical services and sometimes quit the treatment. Psychoeducation as a tool in this area, persuits that patients and family know the nature of the illness, his ethiology, course, therapeutic approaches and outcomes. This article takes evidence sorround psychoeducation in mental health illness, discuss the appliance of the results and the importance of replying and systematization of experiences.
Subject(s)
Humans , Mental Health , Patient Education as Topic/methods , Mental Disorders/therapy , Family , Health Education/methods , Mental Disorders/psychologyABSTRACT
BACKGROUND: Dolutegravir (S/GSK1349572), a once-daily, unboosted integrase inhibitor, was recently approved in the United States for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in combination with other antiretroviral agents. Dolutegravir, in combination with abacavir-lamivudine, may provide a simplified regimen. METHODS: We conducted a randomized, double-blind, phase 3 study involving adult participants who had not received previous therapy for HIV-1 infection and who had an HIV-1 RNA level of 1000 copies per milliliter or more. Participants were randomly assigned to dolutegravir at a dose of 50 mg plus abacavir-lamivudine once daily (DTG-ABC-3TC group) or combination therapy with efavirenz-tenofovir disoproxil fumarate (DF)-emtricitabine once daily (EFV-TDF-FTC group). The primary end point was the proportion of participants with an HIV-1 RNA level of less than 50 copies per milliliter at week 48. Secondary end points included the time to viral suppression, the change from baseline in CD4+ T-cell count, safety, and viral resistance. RESULTS: A total of 833 participants received at least one dose of study drug. At week 48, the proportion of participants with an HIV-1 RNA level of less than 50 copies per milliliter was significantly higher in the DTG-ABC-3TC group than in the EFV-TDF-FTC group (88% vs. 81%, P=0.003), thus meeting the criterion for superiority. The DTG-ABC-3TC group had a shorter median time to viral suppression than did the EFV-TDF-FTC group (28 vs. 84 days, P<0.001), as well as greater increases in CD4+ T-cell count (267 vs. 208 per cubic millimeter, P<0.001). The proportion of participants who discontinued therapy owing to adverse events was lower in the DTG-ABC-3TC group than in the EFV-TDF-FTC group (2% vs. 10%); rash and neuropsychiatric events (including abnormal dreams, anxiety, dizziness, and somnolence) were significantly more common in the EFV-TDF-FTC group, whereas insomnia was reported more frequently in the DTG-ABC-3TC group. No participants in the DTG-ABC-3TC group had detectable antiviral resistance; one tenofovir DF-associated mutation and four efavirenz-associated mutations were detected in participants with virologic failure in the EFV-TDF-FTC group. CONCLUSIONS: Dolutegravir plus abacavir-lamivudine had a better safety profile and was more effective through 48 weeks than the regimen with efavirenz-tenofovir DF-emtricitabine. (Funded by ViiV Healthcare; SINGLE ClinicalTrials.gov number, NCT01263015 .).
