ABSTRACT
The aim of this study was to evaluate somatostatin receptor scintigraphy (SRS) in the staging of patients with small cell lung cancer. Prior to chemotherapy, 20 patients were investigated up to 24 h following an injection of 200 MBq 111In-octreotide. Following chemotherapy and restaging, four patients were re-evaluated. Primary tumour was detected in 18 of 23 studies, which exhibited increasing target-to-back-ground ratios over time. Lymph node metastases and distant metastases were detected in 7 of 27 and 8 of 31 sites, respectively. Thus, the overall sensitivity for detecting metastases was less than 26%. SRS did not result in any upstaging of patients. We conclude that in patients with small cell lung cancer, functional imaging by SRS has no impact on clinical decision making.
Subject(s)
Carcinoma, Small Cell/diagnostic imaging , Carcinoma, Small Cell/pathology , Indium Radioisotopes , Lung Neoplasms/diagnostic imaging , Lung Neoplasms/pathology , Octreotide/analogs & derivatives , Receptors, Somatostatin/analysis , Aged , Female , Humans , Indium Radioisotopes/pharmacokinetics , Lymphatic Metastasis , Male , Middle Aged , Neoplasm Metastasis , Neoplasm Staging/methods , Octreotide/metabolism , Octreotide/pharmacokinetics , Radionuclide Imaging , Reproducibility of Results , Sensitivity and SpecificityABSTRACT
The aim of this study was to examine patients with long-standing Graves' ophthalmopathy using 111In-octreotide scintigraphy. Sixteen patients with inactive ophthalmopathy of up to 114 months duration and 14 normals were investigated for 48 h following an injection of 200 MBq 111In-octreotide. No significant tracer accumulation in the orbital region could be identified in any of the patients with long-standing Graves' ophthalmopathy. The orbit to brain (O/B) ratios after 24 and 48 h were 2.39 +/- 0.36 and 2.15 +/- 0.44 versus 2.17 +/- 0.33 and 2.20 +/- 0.37 for the patients and normals, respectively (N.S.). 111In-octreotide accumulation in ophthalmopathy described in the literature may thus be a passing event limited to its active stage, which is consistent with the concept of imaging a lymphocytic infiltration. In this study, the lack of accumulation of 111In-octreotide in the orbital region during the inactive stage demonstrates an absence of somatostatin receptors in orbital tissue itself. Thus, in patients with inactive Graves' ophthalmopathy, there is no basis for a diagnostic approach with somatostatin.
Subject(s)
Graves Disease/diagnostic imaging , Indium Radioisotopes , Octreotide , Receptors, Somatostatin/analysis , Case-Control Studies , Female , Humans , Male , Middle Aged , Orbit/diagnostic imaging , Prospective Studies , Radionuclide Imaging , Reference Values , Time FactorsABSTRACT
A simple and inexpensive solution for the complete digital management of a nuclear medical institution is presented. The starting point was provided by five different gamma cameras, one of which was equipped with a PC-based ICON computer. The remaining cameras were first adapted to ICONs and subsequently integrated into a Macintosh LAN, of 15 computers, allowing the entire image acquisition, processing, interpretation, documentation and archiving to be performed on the same comfortable menu-guided surface. Complete patient management is accomplished by a specific commercially available data base to which a specially developed image and document archive was connected. The system described provides complete digital management without the conventional filing systems at the moderate price of approximately DM 11 x 10(4) plus the cost of the new camera computers.
