Subject(s)
Urinary Incontinence, Stress/surgery , Urodynamics , Female , Humans , Postoperative Period , Preoperative CareABSTRACT
The value of veralipride in menopausal disorders is no longer questionable and has been documented by a number of studies. The purpose of this paper is to study the clinical effectiveness and to look for the biological consequences of three months therapy with veralipride. To achieve this, a thorough biological study (hematology, glucids, lipids, hepatic and renal function) was done in 21 patients with a menopausal syndrome before and after taking veralipride for three months. Clinical effectiveness was excellent with 80% satisfactory results. No signs of intolerance or adverse side-effects were seen. We recorded no significant changes in biological parameters. No disturbances of renal or hepatic function were detected, either in individual assessments or in the overall statistical analysis of the study group. Because it is well tolerated, effective, and devoid of adverse metabolic side-effects, we conclude that veralipride is the best non-hormonal treatment for menopausal disorders presently available.
Subject(s)
Climacteric/drug effects , Sulpiride/analogs & derivatives , Clinical Trials as Topic , Female , Humans , Middle Aged , Sulpiride/therapeutic useABSTRACT
The lymphocytotoxicity technique at +15 degrees C and +37 degrees C was used to identify anti-HLA and cold lymphocytotoxic antibodies in sera from two women with herpes gestationis. The degree of severity of the illness was different in the two cases. The more serious case (widespread cutaneous involvement, repeated fetal deaths) had a very powerful anti-HLA-A9 +anti-HLA-B5 antibody (titre 1/1000); the other had less severe skin lesions; she had an anti-HLA-B13 antibody (titre was 1/256). Both cases had cold lymphocytotoxic auto-antibodies.
Subject(s)
HLA Antigens/immunology , Pemphigoid Gestationis/immunology , Pregnancy Complications/immunology , Skin Diseases, Vesiculobullous/immunology , Adult , Antibodies/analysis , Antilymphocyte Serum/analysis , Autoantibodies/analysis , Female , Genotype , Humans , Male , Pedigree , Pemphigoid Gestationis/genetics , Pregnancy , Pregnancy Complications/geneticsABSTRACT
The frequency of maternal anti HLA sensitization was studied in 1401 normal and pathological pregnancies. The analysis of the obstetrical history showed in patients with sensitization, a stabilical highs indications of preceding abortion and premature labors and of actual anemies and premature labors. The signification of such, an association remains to be found.
