1.
Bioorg Med Chem Lett
; 17(16): 4538-44, 2007 Aug 15.
Article
in English
| MEDLINE
| ID: mdl-17574412
ABSTRACT
This manuscript describes the design and synthesis of a series of pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a pre-clinical animal models.