ABSTRACT
BACKGROUND: Palliative care patients, those suffering from at least one chronic lifelong medical condition and hospice care patients, those with a life expectancy less than 6 months, are regularly hospitalised in general internal medicine wards. By means of a clinical case, this review aims to equip the internist with an approach to bleeding in this population. Firstly, practical advice on platelet transfusions will be provided. Secondly, the management of bleeding in site-specific situations will be addressed (from the ENT/pulmonary sphere, gastrointestinal - urogenital tract and cutaneous ulcers). Finally, an algorithm pertaining to the management of catastrophic bleeding is proposed. METHODS: Electronic databases, including EMBASE, Pubmed, Google Scholar and the Cochrane Library were studied as primary resources, in association with local guidelines, to identify papers exploring platelet transfusions and alternative management of site-specific bleeding in palliative care patients. RESULTS: Haemorrhagic complications are frequent in palliative care patients in the internal medicine ward. Current guidelines propose a therapeutic-only platelet transfusion policy. Nonetheless, prophylactic and/or therapeutic transfusion remains a physician-dependent decision. Site-specific therapeutic options are based on expert opinion and case reports. While invasive measures may be pertinent in certain situations, their application must be compatible with patient goals. Catastrophic bleeding requires caregivers' comforting presence; pharmacological management is secondary. CONCLUSION: Literature is lacking regarding management of bleeding in the palliative care population hospitalised in an acute medical setting. Recommendations are of limited quality, the majority based on case reports or expert opinion. Further studies, exploring for example the impact on patient quality of life, are desirable to improve the management of this frequently encountered complication.
ABSTRACT
PURPOSE: To determine in vivo whether a pharmacologically induced change in intraocular pressure (IOP) leads to measurable changes in axial eye length and whether there is a difference between glaucoma patients and control subjects. METHODS: 42 subjects (19 patients with primary open angle glaucoma and 23 control patients matched for age and gender) underwent axial eye length measurement using partial coherence laser interferometry and measurement of IOP using dynamic contour tonometry before and 2 h after oral intake of 500 mg acetazolamide. Student's t-test was used to compare differences in the means. RESULTS: An identical drop in IOP was induced in both the glaucoma (mean+/-SEM: 2.90+/-0.44 mmHg, n=19) and the control group (mean+/-SEM: 3.17+/-0.32 mmHg, n=23). The change in axial eye length was significantly smaller (P=0.026) in the glaucoma group (mean+/-SEM: -14.2+/-3.2 microm, n=19) compared with the control group (mean+/-SEM: -23.0+/-2.98 microm, n=23). CONCLUSIONS: Our results strongly suggest that the ocular rigidity is increased in patients with established glaucoma in comparison to control subjects. Ocular rigidity could play a role in the pathogenesis and pathophysiology of glaucoma. Determination of ocular rigidity could be helpful in detection of glaucoma.
Subject(s)
Eye/physiopathology , Glaucoma, Open-Angle/physiopathology , Acetazolamide/therapeutic use , Aged , Antihypertensive Agents/therapeutic use , Biometry/methods , Cornea/pathology , Elasticity , Eye/pathology , Female , Glaucoma, Open-Angle/diagnosis , Glaucoma, Open-Angle/drug therapy , Glaucoma, Open-Angle/pathology , Humans , Interferometry/methods , Intraocular Pressure/drug effects , Intraocular Pressure/physiology , Lasers , Male , Manometry/methods , Middle AgedABSTRACT
We introduce a simple method of sonographic determination of femoral neck anteversion in children with which the even difficult angels in terms of measurement, those up to 70 degrees, can be measured with sufficient reliability: The examination was done with a defined internal 40 degree rotation of the legs reached by a supporting wedge. We proved this method on 55 children's hips of which we already had an existing radiologic determination of the anteversion angle. Compared to the radiological results we found an average deviation of 3.6 degrees (standard deviation = 3.2).
