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1.
Non-antibiotic drug network reveals new leads for antibiotics.
Eccleston, Alex.
Nat Rev Drug Discov ; 23(5): 339, 2024 May.
Article in English | MEDLINE | ID: mdl-38594354

Subject(s)
Anti-Bacterial Agents , Anti-Bacterial Agents/pharmacology , Humans , Drug Discovery
2.
Suppressing tumour Treg cells with a histone demethylase inhibitor.
Eccleston, Alex.
Nat Rev Drug Discov ; 23(4): 250, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38454144

Subject(s)
Histone Demethylases , Neoplasms , Humans , Neoplasms/drug therapy
3.
Macrocyclic peptides thwart Gram-negative bacteria.
Eccleston, Alex.
Nat Rev Drug Discov ; 23(3): 171, 2024 03.
Article in English | MEDLINE | ID: mdl-38316949

Subject(s)
Gram-Negative Bacteria , Peptides , Humans , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use , Gram-Positive Bacteria
4.
Stalled molecular motor inhibits tumour growth.
Eccleston, Alex.
Nat Rev Drug Discov ; 23(2): 105, 2024 02.
Article in English | MEDLINE | ID: mdl-38216773

Subject(s)
Neoplasms , Humans , DNA Replication
5.
PROTAC in clinic for autoimmune skin disease.
Eccleston, Alex.
Nat Rev Drug Discov ; 23(1): 18, 2024 01.
Article in English | MEDLINE | ID: mdl-38049464

Subject(s)
Autoimmune Diseases , Skin Diseases , Humans , Autoimmune Diseases/drug therapy , Proteolysis
6.
Phosphatase inhibitor drives anticancer immune responses.
Eccleston, Alex.
Nat Rev Drug Discov ; 22(12): 951, 2023 12.
Article in English | MEDLINE | ID: mdl-37914810

Subject(s)
Enzyme Inhibitors , Phosphoric Monoester Hydrolases , Humans , Enzyme Inhibitors/pharmacology , Immunity
7.
Rewired proteostasis in KRAS inhibitor resistance.
Eccleston, Alex.
Nat Rev Drug Discov ; 22(11): 871, 2023 11.
Article in English | MEDLINE | ID: mdl-37758873

Subject(s)
Proteostasis , Proto-Oncogene Proteins p21(ras) , Humans , Proto-Oncogene Proteins p21(ras)/genetics , Mutation , Protein Kinase Inhibitors/pharmacology , Cell Line, Tumor , Drug Resistance, Neoplasm
8.
Clipping cell-surface mucins in cancer by targeted degradation.
Eccleston, Alex.
Nat Rev Drug Discov ; 22(10): 783, 2023 Oct.
Article in English | MEDLINE | ID: mdl-37626206
9.
A strategy for small-molecule RNA degraders.
Eccleston, Alex.
Nat Rev Drug Discov ; 22(8): 621, 2023 08.
Article in English | MEDLINE | ID: mdl-37407753
10.
Peptide vaccine turns up the heat in ALK-positive cancers.
Eccleston, Alex.
Nat Rev Drug Discov ; 22(9): 696, 2023 09.
Article in English | MEDLINE | ID: mdl-37524810
11.
A ROS-mediated resistance pathway to anticancer drugs.
Eccleston, Alex.
Nat Rev Drug Discov ; 22(7): 534, 2023 07.
Article in English | MEDLINE | ID: mdl-37277606

Subject(s)
Antineoplastic Agents , Humans , Reactive Oxygen Species/metabolism , Reactive Oxygen Species/pharmacology , Antineoplastic Agents/pharmacology , Antineoplastic Agents/therapeutic use , Apoptosis , Cell Line, Tumor
12.
Investigating menin inhibitor action in leukaemia.
Eccleston, Alex.
Nat Rev Drug Discov ; 22(5): 352, 2023 05.
Article in English | MEDLINE | ID: mdl-37016125

Subject(s)
Leukemia , Humans , Leukemia/drug therapy , Protein Binding
13.
Ribosome inhibitor combats bacterial drug resistance.
Eccleston, Alex.
Nat Rev Drug Discov ; 22(4): 267, 2023 04.
Article in English | MEDLINE | ID: mdl-36894636

Subject(s)
Anti-Bacterial Agents , Ribosomes , Humans , Anti-Bacterial Agents/pharmacology , Anti-Bacterial Agents/therapeutic use , Drug Resistance, Bacterial
14.
CRISPR base editing protects the heart.
Eccleston, Alex.
Nat Rev Drug Discov ; 22(3): 179, 2023 03.
Article in English | MEDLINE | ID: mdl-36725926

Subject(s)
Clustered Regularly Interspaced Short Palindromic Repeats , Gene Editing , Humans , CRISPR-Cas Systems
15.
Cartilage regeneration for osteoarthritis.
Eccleston, Alex.
Nat Rev Drug Discov ; 22(2): 96, 2023 02.
Article in English | MEDLINE | ID: mdl-36599921

Subject(s)
Cartilage , Osteoarthritis , Humans , Osteoarthritis/drug therapy , Regeneration
16.
Transcription reprogramming to enhance CAR-T cell function.
Eccleston, Alex.
Nat Rev Drug Discov ; 22(1): 16, 2023 01.
Article in English | MEDLINE | ID: mdl-36446914

Subject(s)
Immunotherapy, Adoptive , Receptors, Chimeric Antigen , Humans , Receptors, Chimeric Antigen/genetics , T-Lymphocytes , Receptors, Antigen, T-Cell
17.
Brain-selective kinase inhibition.
Eccleston, Alex.
Nat Rev Drug Discov ; 21(11): 797, 2022 11.
Article in English | MEDLINE | ID: mdl-36198872

Subject(s)
Brain , Neurons , Humans
18.
HIF1α reboots fetal haemoglobin production.
Eccleston, Alex.
Nat Rev Drug Discov ; 21(12): 878, 2022 12.
Article in English | MEDLINE | ID: mdl-36307651

Subject(s)
Fetal Hemoglobin , Humans , Fetal Hemoglobin/genetics
19.
RNA structure guides antiviral ASO design.
Eccleston, Alex.
Nat Rev Drug Discov ; 21(10): 714, 2022 10.
Article in English | MEDLINE | ID: mdl-36008548

Subject(s)
Antiviral Agents , RNA , Antiviral Agents/pharmacology , Antiviral Agents/therapeutic use , Humans , Oligonucleotides, Antisense/genetics , RNA, Messenger/genetics
20.
Phenotypic screen with deep learning finds cardioprotective molecules.
Eccleston, Alex.
Nat Rev Drug Discov ; 21(9): 634, 2022 09.
Article in English | MEDLINE | ID: mdl-35896800

Subject(s)
Deep Learning , Humans
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