ABSTRACT
BACKGROUND: Ringworm is highly prevalent in our setting and is frequently observed in our routine clinical practice. Diagnostic confirmation depends on techniques that are not always accessible (PCR), with highly variable sensitivity depending on the observer (direct microscopy) or delayed results (culture, histopathology). Recently, an immunochromatography-based rapid test (Diafactory®) for the antigenic detection of dermatophytes has been developed. This diagnostic tool can help diagnose ringworm, allowing early initiation of treatment and fewer consultation visits. OBJECTIVE: To determine the sensitivity and specificity of the rapid antigen detection test compared to conventional culture. MATERIAL AND METHODS: For a full year, 333 nail samples were collected from patients with suspected onychomycosis. The rapid test and the conventional culture were simultaneously performed on each sample. Those with a positive antigenic test result began treatment early. The remaining patients had appointments for serial cultures and subsequent medical consultation to evaluate the results. RESULTS: Compared to conventional culture, the sensitivity and specificity rates of the rapid antigen detection test are 97.2% and 80.7%, respectively. CONCLUSION: The effectiveness of the rapid antigen detection test is similar to that of conventional culture for the detection of dermatophytes in nail samples. It is a quick and simple diagnostic technique that reduces the number of patient visits to the hospital, and allows early treatment start.
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Histiocytoma, Benign Fibrous , Skin Neoplasms , Soft Tissue Neoplasms , Adolescent , Female , Humans , UltrasonographyABSTRACT
No disponible
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Humans , Teledermatology , Family Practice/trends , Physicians, Family , Primary Health CareABSTRACT
No disponible
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Humans , Male , Middle Aged , Aged , Leishmaniasis, Cutaneous/diagnostic imaging , Leishmaniasis, Cutaneous/drug therapy , Amphotericin B/administration & dosage , Antiprotozoal Agents/administration & dosage , Meglumine Antimoniate/administration & dosage , UltrasonographyABSTRACT
No disponible
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Humans , Female , Middle Aged , Adenocarcinoma/diagnosis , Lung Neoplasms/diagnosis , Skin Neoplasms/diagnosis , Dermis/diagnostic imaging , Adenocarcinoma/pathology , Lung Neoplasms/pathology , Skin Neoplasms/pathology , Skin Neoplasms/secondary , Neoplasm Metastasis/pathology , Dermis/pathologyABSTRACT
Photodynamic therapy (PDT) involves the use of photochemical reactions mediated through the interaction of photosensitizing agents, light, and oxygen for the treatment of malignant or benign diseases. Topical photosensitizers employed in dermatology are 5-aminolevulinic acid (5 ALA) and methyl aminolevulinate, classically used for the treatment of superficial non-melanoma skin cancer and their precursors. Recently the efficacy of PDT has been introduced in other benign diseases. Elastosis perforans serpiginosa (EPS) is a rare skin disorder characterized by transepidermal elimination of abnormal elastic fibers. Management of this condition is complicated, various methods have been used but with limited success. We report a case of EPS in a 30-yeard-old woman treated with 5 ALA-PDT. After 4 sessions the lesions have almost completely disappeared with no residual side effects. Therefore we present an effective and safe alternative for the treatment of EPS.
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Aminolevulinic Acid/therapeutic use , Photochemotherapy/methods , Photosensitizing Agents/therapeutic use , Skin Diseases/drug therapy , Adult , Female , HumansABSTRACT
No disponible
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Humans , Female , Child , Xanthogranuloma, Juvenile , Echocardiography, Doppler, Color/methods , Diagnosis, Differential , Histiocytes/pathologyABSTRACT
No disponible
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Humans , Male , Female , Adult , Middle Aged , Histiocytoma, Benign Fibrous , Microscopy, Confocal/instrumentation , Microscopy, Confocal/methods , Histiocytoma, Benign Fibrous/surgery , Diagnosis, Differential , Ultrasonography, Doppler, Color/instrumentation , Ultrasonography, Doppler, Color/methods , Ultrasonography, Doppler, ColorABSTRACT
No disponible
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Humans , Male , Female , Pregnancy , Adult , Psoriasis/complications , Psoriasis/therapy , Biological Therapy/methods , Biological Therapy , Pregnancy Complications/epidemiology , Maternal-Fetal Exchange , Maternal-Fetal Exchange/immunologySubject(s)
Adalimumab/therapeutic use , Dermatologic Agents/therapeutic use , Etanercept/therapeutic use , Pregnancy Complications/drug therapy , Psoriasis/drug therapy , Ustekinumab/therapeutic use , Abnormalities, Drug-Induced , Abortion, Induced , Adalimumab/adverse effects , Databases, Factual , Dermatologic Agents/adverse effects , Etanercept/adverse effects , Female , Fetal Membranes, Premature Rupture , Humans , Infant, Newborn , Male , Pregnancy , Registries , Respiratory Distress Syndrome, Newborn , Ustekinumab/adverse effectsSubject(s)
Histiocytoma, Benign Fibrous/diagnostic imaging , Skin Neoplasms/diagnostic imaging , Ultrasonography, Doppler , Abdomen , Adult , Arm , Carcinoma, Squamous Cell , Female , Histiocytoma, Benign Fibrous/blood supply , Humans , Male , Middle Aged , Neoplasms, Second Primary/diagnostic imaging , Pharyngeal Neoplasms , Skin Neoplasms/blood supplyABSTRACT
No disponible
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Humans , Female , Middle Aged , Ultrasonography/instrumentation , Ultrasonography/methods , Ultrasonography , Poroma/classification , Poroma/diagnosis , Poroma/pathology , Prognosis , Codeine/adverse effects , Codeine/pharmacology , Codeine/therapeutic use , Epidermis/surgerySubject(s)
Breast/diagnostic imaging , Fat Necrosis/diagnostic imaging , Mammaplasty/adverse effects , Postoperative Complications/diagnostic imaging , Subcutaneous Fat/diagnostic imaging , Ultrasonography, Mammary , Breast Neoplasms/drug therapy , Breast Neoplasms/surgery , Carcinoma, Ductal, Breast/drug therapy , Carcinoma, Ductal, Breast/surgery , Combined Modality Therapy , Diagnosis, Differential , Fat Necrosis/etiology , Fat Necrosis/pathology , Female , Fibrosis , Humans , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Postoperative Complications/etiology , Postoperative Complications/pathologySubject(s)
Adenoma, Sweat Gland/diagnostic imaging , Poroma/diagnostic imaging , Ultrasonography , Female , Humans , Middle AgedABSTRACT
No disponible
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Female , Humans , Middle Aged , Neurothekeoma , Skin Neoplasms , Diagnosis, DifferentialABSTRACT
Antecedentes: La fototerapia es una opción terapéutica empleada en dermatitis atópica (DA) y recomendada en múltiples guías. Objetivos: Evaluar la eficacia de las distintas modalidades de fototerapia y fotoquimioterapia en el tratamiento de pacientes con DA moderada-grave, mediante una revisión sistemática. Material y métodos: Consideramos los ensayos clínicos aleatorizados (ECA) realizados en pacientes con DA, aceptando cualquier medida de desenlace. Localizamos los artículos mediante una búsqueda electrónica, utilizando Medline (vía Ovid), Embase y Cochrane Central Register of Controlled Trials. Adicionalmente, buscamos los ensayos clínicos registrados en Current Controlled Trials y en la WHO International Clinical Trials Registry Platform. Resultados: Incluimos 21 ECA en el análisis cualitativo (961 pacientes). Dos ECA incluyeron niños y adolescentes (32 pacientes). Las modalidades UVBBE y UVA1 mostraron resultados de eficacia similares en diversas medidas de desenlace. Dos ECA incluyeron la terapia PUVA. No se describieron efectos secundarios graves. En general, el riesgo de sesgos fue elevado y la calidad de las publicaciones baja, en cuanto a comunicación de la metodología empleada y los resultados obtenidos. Conclusiones: Existe evidencia para el uso de UVBBE y UVA1 en DA moderada-grave. La evidencia para el uso de PUVA en DA es mínima, así como los datos del uso de la fototerapia en la infancia. En futuros estudios sería recomendable estandarizar los criterios de gravedad de la DA y las escalas de valoración de los pacientes, homogeneizar las técnicas de irradiación y establecer un periodo de seguimiento mínimo (AU)
Background: Phototherapy is a treatment option for atopic dermatitis recommended by several guidelines. Objective: To perform a systematic review of the efficacy of different modalities of phototherapy and photochemotherapy in moderate to severe atopic dermatitis. Material and methods: We considered all randomized clinical trials (RCTs) performed in patients with atopic dermatitis, and accepted all outcome measures. Articles were identified via an online search of the MEDLINE (via Ovid) and Embase databases and the Cochrane Central Register of Controlled Trials. We also searched for clinical trials registered in Current Controlled Trials and in the World Health Organizations International Clinical Trials Registry Platform. Results: Twenty-one RCTs (961 patients) were included in the qualitative analysis. Two of the trials included children and adolescents (32 patients). The efficacy of narrow-band UV-B and UV-A1 phototherapy was similar for the different outcome measures contemplated. Two RCTs assessed the efficacy of psoralen plus UV-A therapy (PUVA). No serious adverse events were described. In general, the publications reviewed were characterized by a high risk of bias and poor reporting of methodology and results. Conclusions: There is evidence for the use of narrow-band UV-B and UV-A1 phototherapy in moderate to severe atopic dermatitis. Evidence supporting the use of PUVA in atopic dermatitis is scarce and there is little information on the use of phototherapy in childhood. For the purpose of future studies, it would be advisable to use comparable criteria and scales for the evaluation of disease severity and patients, to standardize radiation methods, and to establish a minimum follow-up time (AU)
