ABSTRACT
BACKGROUND: Visceral adiposity index (VAI) is a proposed parameter to evaluate visceral obesity instead of waist circumference (WC) in patients with polycystic ovary syndrome (PCOS). We aimed to evaluate VAI levels in overweight and/or obese, and non-obese PCOS patients and investigate the association between metabolic and inflammatory parameters. METHODS: Seventy-six PCOS patients between 18 and 40, and 38 age- and BMI-matched controls were enrolled into the study. Both PCOS groups and controls were classified into two subgroups according to body mass index (BMI) <25 and ≥25 kg/m2. RESULTS: In PCOS patients, waist/hip ratio (WHR) (p = 0.023), diastolic blood pressure (DBP) (p = 0.001), insulin (p = 0.011), homeostasis of model assessment (HOMA-IR) (p = 0.006) and uric acid (UA) (p = 0.002) were higher than controls. In overweight and/or obese PCOS group, DBP (p < 0.001), insulin (p = 0.002), HOMA-IR (p = 0.001), triglyceride (p = 0.015) and VAI (p = 0.031) were higher than overweight and/or obese controls. In non-obese PCOS group, WHR (p = 0.016), WC (p = 0.030), DBP (p = 0.010) and UA (p < 0.001) were higher than non-obese controls. Similar VAI levels were found in all PCOS and non-obese PCOS subgroups than peer controls. Overweight and/or obese PCOS group had higher VAI levels than non-obese PCOS group (p < 0.001). VAI levels were positively correlated with WHR, glucose, HOMA-IR, high-sensitive CRP and UA in PCOS group. In controls, VAI levels were positively correlated with WHR, insulin and HOMA-IR. CONCLUSION: We found that VAI levels were higher in overweight and/or obese PCOS patients compared to peer controls and non-obese PCOS patients, and associated with some metabolic and inflammatory parameters.
Subject(s)
Adiposity , Inflammation/blood , Obesity, Abdominal/blood , Overweight/blood , Polycystic Ovary Syndrome/blood , Adult , Blood Glucose/metabolism , Body Mass Index , Female , Follow-Up Studies , Humans , Inflammation/complications , Inflammation/physiopathology , Inflammation Mediators/metabolism , Insulin/blood , Insulin Resistance , Male , Obesity, Abdominal/complications , Obesity, Abdominal/physiopathology , Overweight/complications , Overweight/physiopathology , Polycystic Ovary Syndrome/complications , Polycystic Ovary Syndrome/physiopathology , Prognosis , Prospective Studies , Waist Circumference , Waist-Hip Ratio , Young AdultABSTRACT
BACKGROUND AND AIM: Acute pancreatitis (AP), an inflammatory disorder of the pancreas, is associated with significant morbidity and mortality. The pathogenesis of AP has been suggested to -involve high oxidative stress (OS), combined with inadequate antioxidant status. We aimed to investigate the levels of serum total anti-oxidant status (TAS), total oxidant status (TOS) and ischemia-modified albumin (IMA) in patients with mild AP2016. METHODS: Thirty subjects with mild AP and 29 healthy controls were enrolled into the study. The levels of TAS, TOS and IMA, C-reactive protein (CRP), high sensitivity CRP (hs-CRP) and fibrinogen were measured in both groups. RESULTS: TAS levels were significantly lower (pâ=â0.037), while IMA levels were significantly higher (pâ<â0.001) in patients, compared to controls. TOS levels were similar between two groups. Fibrinogen, CRP and hs-CRP levels were significantly higher in patients than those of controls (pâ<â0.001 for all parameters). IMA levels were positively correlated with amylase and lipase levels (râ=â0.448, pâ=â0.001 and râ=â0.469, pâ<â0.001, respectively). There was a negative correlation between TAS levels, and amylase and lipase levels (râ=â-0.277, pâ=â0.035 and râ=â-0.278, pâ=â0.034, respectively). CONCLUSION: OS is reported to be associated with the inflammatory process and the severity of AP. In our study, among OS parameters, an increase in IMA levels and a decrease in TAS levels were observed in mild AP patients.
Subject(s)
Amylases/metabolism , Antioxidants/metabolism , C-Reactive Protein/metabolism , Fibrinogen/metabolism , Lipase/metabolism , Oxidants/metabolism , Pancreatitis/metabolism , Serum Albumin/metabolism , Acute Disease , Adult , Aged , Biomarkers/metabolism , Case-Control Studies , Female , Humans , Male , Middle Aged , Oxidative Stress , Serum Albumin, Human , Severity of Illness IndexABSTRACT
We describe a case with the simultaneous occurrence of chronic myelogenous leukemia (CML) and non-Hodgkin lymphoma (NHL). Peripheral blood (PB) and bone marrow (BM) smears showed typical CML features. Lymph node biopsy exhibited a large-cell NHL. The Philadelphia chromosome or its molecular counterpart, the BCR-ABL gene fusion, by detecting with dual color-(DC) fluorescence in situ hybridization (FISH), was detected reliably both in metaphase spreads from BM and in interphase nuclei from BM and follow-up PB cells, but was not detected in the lymph node cells. Clinical features and laboratory findings show this case having a coexistence of CML and NHL.
Subject(s)
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications , Lymphoma, Non-Hodgkin/complications , Adult , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bone Marrow/pathology , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Female , Fusion Proteins, bcr-abl/genetics , Humans , In Situ Hybridization, Fluorescence , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology , Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Non-Hodgkin/genetics , Lymphoma, Non-Hodgkin/pathology , Prednisone/administration & dosage , Vincristine/administration & dosageABSTRACT
The closed rupture of the pericardium without accompanying intrathoracal injuries, is a rare lesion. These cases are diagnosed generally at autopsy. Authors describe a case, successfully treated by operation.
