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Bioorg Med Chem Lett ; 16(17): 4458-61, 2006 Sep 01.
Article in English | MEDLINE | ID: mdl-16844371

ABSTRACT

A new cyclic nonapeptide, segetalin F, has been isolated from the seeds of Vaccaria segetalis and the structure including absolute stereochemistry was elucidated by using 2D NMR and chemical means. A series of segetalins showed a vasorelaxant activity against norepinephrine (NE)-induced contractions of rat aorta.


Subject(s)
Peptides, Cyclic/chemistry , Peptides, Cyclic/pharmacology , Vaccaria/chemistry , Vasodilation/drug effects , Animals , Aorta/drug effects , Magnetic Resonance Spectroscopy , Molecular Structure , Plant Extracts/chemistry , Plant Extracts/pharmacology , Rats , Seeds/chemistry
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