[Anti-aggregant activity of the blood vessel wall and its regulation by GABAergic agents in hypokinesia]. / Antiagregantnaia aktivnost' sosudistoi stenki i vozmozhnost' ee reguliatsii GAMK-ergicheskimi sredstvami v usloviiakh gipokinezii.

Restricted motor activity on the background of platelet hyperaggregation in the whole blood and plasma leads to inhibition of the antiaggregant activity of the blood vessel wall, thus creating prerequisites for the development of thromboembolic disturbances. Under these conditions, GABA and piracetam produce a pronounced protective action with respect to the platelet-vessel wall interactions.

[The effect of GABA-ergic agents on the electrolyte balance under hypokinesia]. / Vliianie GAMK-ergicheskikh sredstv na balans élektrolitov v usloviiakh gipokinezii.

The effect of hypokinesia on the blood electrolyte balance was studied. In restricted motor activity marked deviations of the type of hypokalemia and hypercalcemia were encountered, which could promote the development of various pathological processes, including disorder of central and regional hemodynamics. GABA and piracetam had no effect on the blood serum electrolyte content in the early periods of hypokinesia. In later periods of hypokinesia both drugs under examination corrected the disorders of blood electrolyte balance induced by prolonged restriction of motor activity.

[Effect of GABA and piracetam on on ATPase activity in brain and liver mitochondria in experimental hypokinesis]. / Vliianie GAMK i piratsetama na ATF-aznuiu aktivnost' mitokhondrii mozga i pecheni v usloviiakh éksperimental'noi gipokinezii.

Long-term hypokinesia is accompanied by changes in the activity of Mg(2+) and 2,4-dinitrophenol (DNP)-stimulated ATPases of rat brain and liver mitochondria. These changes are phasic and especially pronounced at periods characterised by most pronounced metabolic alterations Treatment of animals with GABA and piracetam tends to normalise the enzyme activities.

[The effect of GABA and piracetam on the qualitative and quantitative composition of the brain phospholipids in rats under hypokinetic conditions]. / Vliianie GAMK i piratsetama na kachestvennyi i kolichestvennyi sostav fosfolipidov golovnogo mozga krys v usloviiakh gipokinezii.

The influence of hypokinesia on phospholipid composition of the brain tissue was investigated. Hypokinesia was found to cause significant disorders in the phospholipid composition. Changes exhibit a phase character and are more pronounced on the 15-th and 30-th days of hypokinesia. The use of GABA and pyracetam promotes the processes aimed at normalization of the phospholipid metabolism in the brain tissue.

[Cerebral blood flow and thrombocyte aggregation at different times of hypokinesia and their regulation by antiaggregants]. / Mozgovoi krovotok, agreguemost' trombotsitov v razlichnye sroki gipokinezii i ikh reguliatsiia antiagregantami.

Changes in local cerebral blood flow and in microcirculatory channels in the cortex of rat brain were studied in conditions of early and remote hypokinesia. The rheological parameters of blood were studied in patients which stayed in ber for a long time in traumatological hospitals. We showed that by the 60th day of hypokinesia and in conditions of active readaptation the disordered cerebral blood flow starts to stabilize and tendency to normalization of some parameters of the cerebral blood flow and microcirculatory channels become clearly seen. The study of the functional state of the platelets showed that prescription of antiaggregants along with physical training can prevent thromboembolic aggravations associated with hypokinesia.