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1.
J Pharm Bioallied Sci ; 15(Suppl 1): S486-S489, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37654259

ABSTRACT

Aim: To compare the postoperative complications of fixing Mandibular angle fractures with two non-compression mini plates, on the superior and lateral the aspects of the mandible, to the standard technique of using a single non-compression miniplate on the superior border. Methodology: Fifty patients with MAF were divided equally into two groups. Patients in Group 1 were secured with two mini plates at the lateral and superior border of the MA using an extraoral approach; for patients in Group 2 a single non-compression miniplate was used via an intraoral extended third molar approach as described by Champy et al. The post-operative complications in both groups were compared statistically. Results: The findings of this study revealed that there was no significant difference in postoperative complications between the two groups when fixing MAF with two non-compression mini plates versus the standard technique of using a single non compression miniplate on the superior border of the mandible. However, the surgery time with one miniplate was significantly more than the dual plate approach. Conclusion: We advocate using two mini plates to treat an unfavorable angle fracture.

2.
J Pharm Bioallied Sci ; 15(Suppl 1): S821-S824, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37654362

ABSTRACT

Hypertension rightfully termed as "Silent killer" is associated with increase in morbidity and mortality when left untreated. Calcium channel blockers are the most commonly prescribed first-line anti-hypertensive drugs in India. Calcium channel blockers are known to cause gingival hyperplasia but with lower incidence rates compared to the other two groups causing iatrogenic gingival overgrowth, immunosuppressants, and anticonvulsants. Nifedipine administration, among the calcium channel blockers, has been frequently associated with iatrogenic gingival hyperplasia. Incidence of amlodipine-induced gingival hyperplasia which has similar pharmacodynamic action like nifedipine, had been reported rarely. Here, we present a case series of drug induced gingival overgrowth caused by calcium channel blockers used for the management of hypertension. All the patient's condition improved after withdrawal of the offending drug, oral prophylaxis and intervention, and alternate drug from other first-line drugs were started for managing hypertension.

3.
Cureus ; 14(9): e29295, 2022 Sep.
Article in English | MEDLINE | ID: mdl-36277531

ABSTRACT

Purpose:​​​​​ This study aimed to evaluate the masticatory forces in patients treated for mandibular fractures. To assess the magnitude of damage to the masticatory system caused by the various mandibular fractures and the period required for their normalization. Materials and Methods: Data were recorded from the authentic and original bite force measurement device from 2015 to 2017. The sample was composed of 30 isolated mandible fractures patients, Group 1 consisting 15 patients with unilateral mandible fractures, Group 2 consisting 15 patients with bilateral mandible fractures, treated with ORIF (open reduction immobilization fixation) under general anesthesia, and Group 3 was a control group. Predictor variables were drawn from predefined intervals for three months (ninth POW) postoperative week. The condition of wound healing was checked, and masticatory forces are measured at the first, fourth, sixth, and ninth postoperative weeks and compared with a control group of the same age and gender. The outcome variables were the success rate and associated complications. Results: For the study, a total of 30 patients with 15 bilateral and 15 unilateral isolated mandibular fractures were included. The study result suggests that the patient had lower bite forces relative to the control group at all intervals. All patients showed a significant increase in the bite force values from the first to the fourth postoperative weeks (p = Conclusion: ​​​​ Based on the results obtained from our study, we conclude that there is a temporary adverse effect on masticatory forces. Fracture of the bilateral mandible has a stronger influence on bite force than unilateral mandible fracture. These fractures also take a longer time to normalize.

4.
J Pharm Bioallied Sci ; 13(Suppl 2): S1577-S1582, 2021 Nov.
Article in English | MEDLINE | ID: mdl-35018033

ABSTRACT

AIM: The aim of this study was to evaluate the efficacy of preoperative prophylactic antibiotics of 2 g of oral amoxicillin on bacteremia following extraction of teeth with periodontal and periapical pathology. MATERIALS AND METHODS: This study was carried out on 160 patients. The patients were divided into four groups of forty patients each: two antibiotic groups, with periodontal and periapical pathology, receiving 2 g of oral amoxicillin preoperatively and two control groups, with periodontal and periapical pathology, receiving no amoxicillin preoperatively. Blood samples were collected before the start of the procedure, intraoperatively, and immediately following extraction of teeth. The collected blood samples were cultured and studied for bacterial growth. RESULTS: In the control group patients with periodontal pathology, 17 out of 40 blood samples showed growth of Streptococcus viridans along with Staphylococcus epidermidis. In the control group patients with periapical pathology, 14 out of 40 blood samples showed growth of S. viridans and Staphylococcus aureus. No growth was observed in both the groups on prophylactic antibiotics with 2 g of oral amoxicillin. CONCLUSION: Bacteremia was found in 40% of the control group patients, while there was no bacteremia present in patients with preoperative administration of 2 g of oral amoxicillin.

5.
J Pharm Bioallied Sci ; 13(Suppl 2): S1772-S1777, 2021 Nov.
Article in English | MEDLINE | ID: mdl-35018076

ABSTRACT

Odontomas are the most commonly occurring odontogenic tumor, and earlier they were considered developmental anomaly as the morphodifferentiation of ameloblast does not occur in odontomas. Odontomas are considered hamartoma rather than true neoplasms as histologically they contain odontogenic tissues which are native to the oral cavity. These odontomas are usually asymptomatic and are revealed in radiographic examination but can also present with over-retained deciduous teeth and malocclusion and with other local complications such as infection. Etiology of odontomas is considered to be from genetic, local environmental, and systemic factors. Broadly based on their radiologic and clinical features, they are classified into two types: compound composite odontomas and complex composite odontomas. The odontomas which resemble teeth are called compound composite odontomas and which do not resemble teeth are called complex composite odontomas. Odontomas are called composite odontomas as they contain both epithelial and mesenchymal derivatives. Here, we report two cases of compound composite odontoma, and a case of complex composite odontoma with relevant review of literature.

6.
J Pharm Bioallied Sci ; 12(Suppl 1): S607-S612, 2020 Aug.
Article in English | MEDLINE | ID: mdl-33149529

ABSTRACT

AIMS: The aim of this study was to assess the quality of platelet-rich plasma (PRP) produced by in-house desktop centrifuge method and compare it with that of standardized commercial PRP. MATERIALS AND METHODS: REMI desktop centrifuge was used to prepare PRP and to compare with standardized commercial PRP by calculating the quantity of platelets using Beckman Coulter cell counter in 10 PRP samples and assessing the morphological quality of platelets using JEOL JEM transmission electron microscope (TEM). STATISTICAL ANALYSIS USED: The t test for platelet count in desktop PRP with the test value of therapeutic PRP was 12.618. The P value was <0.001, which was significant statistically. The data followed a normal distribution in normal Q-Q plot for platelet count in desktop centrifuge. So the test samples were not much deviated. RESULTS: The platelet count was lesser than that of standardized commercial PRP. When viewed under JEOL JEM transmission electron microscope, the α granules in platelets were intact and the morphological quality of the PRP was good. CONCLUSIONS: With this study, we have determined that the morphological quality of PRP produced by the in-house desktop centrifuge method is comparable to that of standardized commercial PRP. Though the quantity of platelets was less than 1 million cells/µL, the clinical results were good with desired bone formation, thereby providing good avenue for further research.

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