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J Fr Ophtalmol ; 43(4): 330-333, 2020 Apr.
Article in English | MEDLINE | ID: mdl-32151474

ABSTRACT

Acanthamoeba keratitis due to a genus of free-living amoebae is a severe corneal infection. Treatment of this disease is based on the combined use of antiseptics and other drugs, including azoles. We tested isavuconazole, the latest marketed azole, in vitro, against A. castellanii, A. lenticulata and A. hatchetti. Our results show that isavuconazole presents slight amoebistatic activity against A. castellanii trophozoites but no cysticidal activity. Isavuconazole could be used only in association for management of AK due to A. castellanii.


Subject(s)
Acanthamoeba Keratitis/parasitology , Acanthamoeba/drug effects , Nitriles/pharmacology , Pyridines/pharmacology , Triazoles/pharmacology , Acanthamoeba/classification , Acanthamoeba/growth & development , Acanthamoeba/physiology , Acanthamoeba Keratitis/drug therapy , Acanthamoeba castellanii/drug effects , Acanthamoeba castellanii/growth & development , Acanthamoeba castellanii/physiology , Animals , Dose-Response Relationship, Drug , Humans , Nitriles/therapeutic use , Parasite Encystment/drug effects , Parasitic Sensitivity Tests , Pyridines/therapeutic use , Triazoles/therapeutic use , Trophozoites/drug effects
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