Ethnopharmacology, phytochemistry, chemical ecology and invasion biology of Acanthus mollis L.

ETHNOPHARMACOLOGICAL RELEVANCE: Acanthus mollis L. (Bear's Breeches) is a wide-spread medicinal and ornamental plant and is particularly suited to exemplarily illustrate the diverse aspects of invasion biology by neophytes. Since ancient times, it has been a popular Mediterranean ornamental plant in horticulture and served as model for the decoration of column capitals in architecture. AIM OF THE STUDY: In the present review, we aimed to give an overview about ethnopharmacology, phytochemistry, chemical ecology, and invasion biology of A. mollis. Thus, the importance of plantation cultivation in the presence of ecologically problematic species and environmental protection were emphasized. MATERIALS AND METHODS: We conducted an extensive literature search via screening PubMed, Scopus, and Web of Science, in order to compile the data about A. mollis and its role on invasion biology and thereby attracting attention to the prominence of the horticultural and agricultural cultivation of plant species with a special focus on A. mollis as a model. RESULTS AND CONCLUSION: Phytochemical analyses revealed secondary metabolites from the classes of flavonoids, phenols, phenylpropanoids, anthraquinones arylnaphthalene lignans, phytosterols and others. Extracts of A. mollis and isolated phytochemicals not only exert assorted activities including antioxidant, anti-inflammatory and neuroprotective in murine and human experimental models, but also act against plant parasites (bacteria, insects, mollusks, fungi), protecting the plant from microbial attack and herbivorous predators. A. mollis has been used in traditional medicine to treat dermatological ailments, gastrointestinal diseases, ulcers and even tumors. Nevertheless, the robustness and rapid growth of A. mollis as well as the global horticultural trade facilitated its invasion into fragile ecosystems of Australia, New Zealand, and several other spots around the globe in Northern Europe (Great Britain), Asia (China, India), South Africa, and South America (Argentina). The release of A. mollis from gardens into the wild represents a considerable danger as invasive species are threatening biodiversity and leading to the extinction of domestic plants in the long run. Likewise, the likelihood of other medicinal plants in terms of invasion biology are needed to be fully recognized and discussed.

Biopiracy versus One-World Medicine-From colonial relicts to global collaborative concepts.

BACKGROUND: Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neocolonialism. HYPOTHESIS: The One-World Medicine concept attempts to merge the best of traditional medicine from developing countries and conventional Western medicine for the sake of patients around the globe. STUDY DESIGN: Based on literature searches in several databases, a concept paper has been written. Legislative initiatives of the United Nations culminated in the Nagoya protocol aim to protect traditional knowledge and regulate benefit-sharing with indigenous communities. The European community adopted the Nagoya protocol, and the corresponding regulations will be implemented into national legislation among the member states. Despite pleasing progress, infrastructural problems of the health care systems in developing countries still remain. Current approaches to secure primary health care offer only fragmentary solutions at best. Conventional medicine from industrialized countries cannot be afforded by the impoverished population in the Third World. Confronted with exploding costs, even health systems in Western countries are endangered to burst. Complementary and alternative medicine (CAM) is popular among the general public in industrialized countries, although the efficacy is not sufficiently proven according to the standards of evidence-based medicine. CAM is often available without prescription as over-the-counter products with non-calculated risks concerning erroneous self-medication and safety/toxicity issues. The concept of integrative medicine attempts to combine holistic CAM approaches with evidence-based principles of conventional medicine. CONCLUSION: To realize the concept of One-World Medicine, a number of standards have to be set to assure safety, efficacy and applicability of traditional medicine, e.g. sustainable production and quality control of herbal products, performance of placebo-controlled, double-blind, randomized clinical trials, phytovigilance, as well as education of health professionals and patients.

Biopiracy of natural products and good bioprospecting practice.

BACKGROUND: Biopiracy mainly focuses on the use of biological resources and/or knowledge of indigenous tribes or communities without allowing them to share the revenues generated out of economic exploitation or other non-monetary incentives associated with the resource/knowledge. METHODS: Based on collaborations of scientists from five continents, we have created a communication platform to discuss not only scientific topics, but also more general issues with social relevance. This platform was termed 'PhytCancer -Phytotherapy to Fight Cancer' (www.phyt-cancer.uni-mainz.de). As a starting point, we have chosen the topic "biopiracy", since we feel this is of pragmatic significance for scientists working with medicinal plants. RESULTS: It was argued that the patenting of herbs or natural products by pharmaceutical corporations disregarded the ownership of the knowledge possessed by the indigenous communities on how these substances worked. Despite numerous court decisions in U.S.A. and Europe, several international treaties, (e.g. from United Nations, World Health Organization, World Trade Organization, the African Unity and others), sharing of a rational set of benefits amongst producers (mainly pharmaceutical companies) and indigenous communities is yet a distant reality. In this paper, we present an overview of the legal frameworks, discuss some exemplary cases of biopiracy and bioprospecting as excellent forms of utilization of natural resources. CONCLUSIONS: We suggest certain perspectives, by which we as scientists, may contribute towards prevention of biopiracy and also to foster the fair utilization of natural resources. We discuss ways, in which the interests of indigenous people especially from developing countries can be secured.