[The state of lipid peroxidation and antioxidant defense system in recipients of renal allotransplant].

The peroxidal oxidation of lipids (POL) and antioxidant defense (AOD) system state in the patients blood before renal transplantation performing and on the fourth day after it were studied, depending on kind of familial or potential agonal with beating (DBH) or nonbeating (DNBH) heart donor applied and the presence of complications--delayed renal autotransplant (RAT) function and acute reaction of rejection (ARR). In chronic renal insufficiency, RAT transplantation from cadaver, DNBH and ARR the POL processes intensification and AOD system activity lowering were noted.

[Hormonal-mediator interrelationships in polycystic ovary syndrome]. / Gormonal'no-mediatornye vzaimootnosheniia pri sindrome polikistoznykh iaichnikov.

Examinations of 33 patients with the polycystic ovaries syndrome with measurements of monoamines, ovarian and gonadotropic hormones, and prolactin revealed disordered monoaminergic regulation in all the patients, manifesting by reduced dopamine level in normoprolactinemia and its reduction parallelled by increase of serotonin level in hyperprolactinemia. Disturbances in monoaminergic regulation result in increased level of LH and reduction of FSH levels in all the patients, as well as different prolactin levels. Hyperandrogenism in patients with the polycystic ovaries syndrome and normoprolactinemia is determined by a unidirectional increase of testosterone and androstenedione, whereas in hyperprolactinemia a sharp increase of testosterone content occurs in parallel with decrease of androstenedione level. Normal total estradiol level was associated in all the examinees with manifest relative hypoestrogenism. The detected disorders in hormonal-mediator relationships in patients with the polycystic ovaries syndrome give us new information on the pathogenesis of this condition, which may be important for its diagnosis and treatment.