[Abdominal tuberculosis in children]. / Abdominal'nyi tuberkulez u detei.

OBJECTIVE: To determine the features of diagnosis and clinical course of abdominal tuberculosis in children. MATERIAL AND METHODS: Eighteen children aged from 5 days to 16 years with abdominal tuberculosis have been followed-up throughout 50 years. Diagnostic process implied anamnesis, objective examination, laboratory data and specific samples, ultrasound, X-ray examination, MRI, CT and morphological examination of specimens. RESULTS: Intestinal form was diagnosed in 2 children with abdominal tuberculosis, mesadenitis - 3 patients, liver tuberculosis - 4 ones, tuberculosis of uterine appendages - 3 patients, peritonitis - 6 ones. CT of the abdomen, diaskintest and morphological examination were the most important diagnostic methods. Laparotomy was performed in 16 children. Five cases are decsribed. CONCLUSION: Abdominal tuberculosis in children is mostly secondary. Several anatomical regions are simultaneously involved in specific process. Isolated lesion of one abdominal organ is rare. Active tuberculosis of respiratory organs in pregnant women has a significant negative impact on the fetus and newborns.

[Urogenital tuberculosis in children].

AIM: To analyze the clinical spectrum of urogenital tuberculosis (TB) in children from 1993-1997 to 2013-2017, who were treated at the FSCU "Kiritsy". MATERIALS AND METHODS: Clinical forms of urogenital tuberculosis were diagnosed in 195 children (stage 1) and 158 children (stage 2). Conventional methods of TB diagnosis, including clinical, laboratory, imaging studies, tuberculin skin test and urine culture for BCG were used. In all cases, standard treatment for TB in combination with physiotherapy were performed. RESULTS: When comparing the clinical spectrum of urogenital tuberculosis in children in 1993-1997 yy. (stage 1) and 2013 and 2017 yy. (stage 2), who were treated at the children's tuberculosis clinic "Kiritsy", the authors concluded that during the last 5 years the number of children with urogenital tuberculosis had decreased by 1.5 times (195 children in 1 stage, 158 in 2 stage) and proportion of children with a destructive form of urogenital tuberculosis decreased by 4 times (15 children in stage 1, 4 in stage 2). The contemporary diagnostic methods (urine culture, Diaskintest, ultrasound, instrumental methods) contributed to improved diagnosis of urogenital tuberculosis. Novel powerful antituberculous antibiotics allowed to significantly improve treatment outcomes. RESULTS: 1) The incidence of urogenital tuberculosis in children over the past 5 years has decreased by 1.5 times compared with 90th years of the the last century. 2) At the current stage, the use of urine culture, Diaskintest, ultrasound, x-ray and instrumental methods contributes to the diagnosis of urogenital tuberculosis in children. 3) Multidisciplinary team consisted of pediatricians, pediatric urologists, phthisiopediatric as well as sanitary and educational work in the foci of infection allow to identify the urogenital tuberculosis in children.

[The factors influencing the completeness of skin regeneration in mammals]. / Faktory, vliiaiushchie na polnotu regenratsii kozhi u mlekopitaiushchikh.

In the majority of experimental studies on skin regeneration, which were conducted on the backs of rats and mice, wound healing resulted in the formation of epithelialized scars of the connective tissue. Using various methods to influence the process of skin regeneration in this and other models, we were able to obtain in some cases the organotypic regeneration accompanied by the formation of skin derivatives. We conclude that we have detected factors affecting the extent of posttraumatic skin regeneration in mammals.

[Patterns in the restoration of skin derivatives in warm-blooded animals]. / Zakonomernosti vosstanovleniia derivatov kozhi u teplokrovnykh.

It is known that the skin derivatives in homeothermic animals appear in the early prenatal period of development and do not form during postnatal development. However, during skin regeneration, a process of secondary development, it was shown experimentally on eight homeothermic animals, in which full-layered fragments of skin were removed from different morphofunctional regions of skin, that in the skin regenerates its derivatives are formed: hair, sebaceous and sweat glands, and skin folds. The data obtained suggest that formation of the hair and sebaceous glands requires the presence of special dermal fibroblasts in the young connective tissue of regenerants, which are capable of induction of the potencies of regenerating epidermis for organogenesis.

[Patterns in the completeness of post-traumatic skin regeneration]. / Zakonomernosti polnoty posttravmaticheskoi regeneratsii kozhi.

Variability of morphological structure of regenerating skin depending on the wound location and species is shown. Occasional formation in the regenerating skin of hair follicles, sebaceous and sweat glands, skin folds is observed. The size and structure of skin regenerates depend on the wound contraction which is due to a different degree of skin mobility in various body regions. Experiments demonstrate skin ability for organotypic regeneration. Skin areas having a similar structure in different species show regeneration of the same type.

[Variability in the completeness of posttraumatic skin regeneration in warm-blooded animals]. / Variabel'nost' polnoty posttravmaticheskoi regeneratsii kozhi u teplokrovnykh.

It is generally accepted that skin regeneration in warm-blooded animals always results in scar formation. Still we have found that the skin regenerated in place of full-thick square skin wounds often resemble the normal one rather than the connective tissue scar by structure. Morphological variability of the skin regenerates proved to depend on the wound location and the animal species. The possibility of formation of the skin derivatives (hair follicles, fat and sweet glands, skin folds) has been shown. A classification of the skin regenerates has been proposed. Numerous examples demonstrate the skin ability to give rise to organ-specific regenerates with the morphological features specific for the wound site.

[Reorganization of skin scars on the back of rats]. / Peristroika kozhnykh rubtsov na spinne u krys.

The method of dosed mechanical injuries (DMI) when applied repeatedly to the mature skin scars in the rat's backs leads to their reduction and transformation into the regenerates having the structure resembling that of the normal skin. The more is the number of applications of DMI--the more is the amount of transformed scars.

[Reorganization of regenerates of the dermal type in rats]. / O perestroike regeneratov dermal'nogo tipa u krys.

Skin regenerates being formed on the stomach of rats were exposed to dosed injuries by needles. These injuries have significantly hastened formation of definitive regenerates.

[The possible effect of the mechanical factor on the completeness of the regeneration of the spinal skin in mice]. / O vozmozhnosti vliianiia mekhanicheskogo faktora na polnotu vosstanovleniia kozhi na spine u myshei.

In mouse tissues, regenerates forming in the place of full-thickness skin wounds on the back, were exposed to dosed mechanical injuries. As a result the structure of final regenerates in some animals differed from the scar, that is usually formed after healing of this type of wound.

[Healing of abdominal skin wounds in rats]. / Osobennosti zazhivleniia kozhnykh ran na briushnoi storone tulovishcha u krys.

The studies performed on rats have shown that healing of square full-tissue skin wounds depends on their location. Thus, the healing of wounds on the belly was faster and more complete than that of dorsally located ones. Regeneration of belly skin resulted in the formation of new tissue with a typical network of fibers and skin folds. On the back epithelial connective tissue scars were formed.

[Effect of dibunol liniment on posttraumatic skin regeneration in mice]. / Vliianie linimenta dibunola na posttravmaticheskuiu regeneratsiiu kozhi u myshei.

The effect of dibunol liniment (5-50 mg/kg) on excised mouse skin was studied. The liniment caused complete skin regeneration with hair and gland formation in the majority of treated mice. Application of the liniment led to a considerable increase in proliferative activity of skin epithelial cells and inhibition of wound area reduction within the first day of healing as compared with controls.

[Variations in the completeness of skin regeneration during post-traumatic regeneration]. / O variatsiiakh polnoty vosstanovleniia kozhi pri posttravmaticheskoi regeneratsii.

The healing of the full-thickness skin wounds on the abdomen and the back of hedgehogs was investigated. The wound healing on the abdomen proved to result mainly from the wound contraction. In most cases a small regenerated area containing new hair and sebaceous glands was formed in the centre of the wound. Contraction of the wound was practically absent on the back and its healing occurred chiefly by new tissue formation; due to this vast regenerated areas were formed in the wound. Connective tissue frame-work of the regenerated area on the abdomen and the back resembled intact derma by fiber distribution.

[Regeneration of mammalial plantar skin]. / Osobennosti regeneratsii kozhi na podoshve u mlekopitaiushchikh.

Two sole tubers of rat's hind leg were excised together with the surrounding skin and one of the hind tubers of hind and fore legs in hedgehogs were excised without the surrounding skin. During healing the skin wounds in rats and hedgehogs new skin proved to form with the papillary layer typical of the sole skin. In hedgehogs the new skin covered the regenerated sole tuber; in rats the sole tubers failed to regenerate.

[Skin regeneration in several species of mammals]. / Ob osobennostiakh regeneratsii kozhi u nekotorykh vidov mlekopitaiushchikh

The healing of full-thickness wounds (1.2 cm2) was studied in minks and sables. The wound closure in both animal species resulted mainly from the contraction of the wound. A small regenerate containing hair and sebaceous glands was formed in the centre of the wound. It is supposed that these hairs developed from the old hair roots transfered with the lower layers of the corium adjoining the wound.

[Completeness of skin regeneration]. / O polnote regeneratsii kozhi

Healing of the wound involving full thickness of the skin was investigated in carnivorous mammals (cats, foxes, polar foxes). Square wounds (2.2 cm2) were inflicted on the back and the head of cats and onthe thigh of foxes and polar foxes. In all the animals investigated the wounds closed chiefly by contracture of their margins. A small regenerate was formed in the centre of the wounds; its structure was almost the same as that of the intact skin: there were hair and sebaceous glands. Connective tissue skeleton of the regenerate resembled the derma by the fiber distribution.