[The epidemiologically valid comparative evaluation of informativeness of techniques of laboratory diagnostic of zooanthroponosic trichophytosis.]

The analysis of long standing morbidity of zooanthroponosis trichophytosis was carried out. The comparative laboratory analysis (microscopy, mycologic technique, polymerase chain reaction) of clinical samples from 111 patients (aged 7-14 years) with clinical diagnosis of trichophytosis (T.verrucosum), 110 patients (aged 3-14 years) with clinical diagnosis of trichophytosis (T.mentagrophytes) and 186 patients with other dermatological diseases (psoriasis, eczema) (negative control). It is demonstrated that in evaluation of diagnostic effectiveness of laboratory methods in case of mycosis induced by T.verrucosum and T.mentagrophytes the optimal choice is the examination of groups of children aged 7-14 and 3-14 years correspondingly. Under trichophytosis (T.verrucosum) sensitivity of polymerase chain reaction amounted to 98.2 (96.5-99.9)%; p<0.05, specificity - 97.5 (95.1-99.9)%; p<0.05 and diagnostic effectiveness - 97.9 (95.9-99.9)5; p<0.05. Under trichophytosis (T.mentagrophytes) sensitivity of polymerase chain reaction corresponded to 97.3 (94.8-99.8)%; p<0.05, specificity - 97.1 (94.6-99.6)%; p<0.05 and diagnostic effectiveness - 97.2 (95-99.4)5; p<0.05.

[Epidemiologic indices of cervical cancer morbidity in areas with various levels of industrial pollution]. / Epidemiologicheskie osobennosti raka sheiki matki na territoriiakh s razlichnymi urovniami tekhnogennogo zagriaznenia.

While general cervical carcinoma morbidity is on the decline in most of the surveyed Russian Federation areas characterized by varying levels of industrial pollution, the heavily industrialized region of Salavat revealed a different tendency. Its level was 1.6 times (p<0.05) those in other areas. That was due to the morbidity of women aged 40-69 and even 20-29 and 30-39 years.

[Detection and study of the labile toxic factor of Proteus mirabilis]. / Obnaruzhenie i izuchenie labil'nogo toksicheskogo faktora Proteus mirabilis.

The author studied the dynamics of toxin formation of the high- and low-virulent Pr. mirabilis strains. The high-virulent strain produced toxic substances of the exotoxin type detectable in 1-2-day broth cultures. Later the activity of the culture medium of both cultures under study was due to substances of the endotoxin type. By physico-chemical and immunobiological properties, and also by chemical composition of Pr. mirabilis "early toxin" was similar to the exoenterotoxins of enterobacteria. A principal possibility of concentration and purification of Pr. mirabilis "early toxin" with the use of ultrafiltration and gel-chromatography was demonstrated.