ABSTRACT
The cytochemical indicators of neutrophils of peripheral blood were analyzed in 30 patients with hypertension disease and isolated traumas of long tubular bones of lower extremities. It is established that in such patients the variations of microbicidal neutrophils systems manifest in the increase of content of cationic proteins and non-significant decrease of myeloperoxidase activity. This is one of mechanisms of immunity support during first 48 hours after trauma.
Subject(s)
Hypertension/metabolism , Leg Bones/injuries , Neutrophils/enzymology , Peroxidase/blood , Adult , Antimicrobial Cationic Peptides/blood , Antimicrobial Cationic Peptides/metabolism , Blood Proteins/metabolism , Female , Humans , Male , Middle Aged , Neutrophils/cytology , Neutrophils/immunology , Peroxidase/metabolismABSTRACT
The functional state of neutrophilic leukocytes in peripheral blood (content of cation protein) was studied in 30 healthy donors an in 32 patients with arterial hypertension who have been residing in the North for a long time. The mean age of the examinees was 49. It was found that the changing functional condition of neutrophils is evidenced in healthy Northerners by a lower content of cation proteins versus the reference values. As for the patients with arterial hypertension, the content of the above proteins in their neutrophilic leukocytes was higher, versus the healthy subjects, and closer to the reference values.
Subject(s)
Blood Proteins/analysis , Hypertension/blood , Neutrophils/chemistry , Adult , Cations , Female , Humans , Male , Middle Aged , Reference Values , RussiaABSTRACT
Bromantan (20 mg/kg, p.o.) and sydnocarb (10 mg/kg, p.o.) augment the efficacy of a 5-h operant activity in rats, the effect being achieved through different pathways. Sydnocarb increases the number of operant reactions and exhausts the sympathico adrenal system reserves. Bromantan favors the activity optimization by reducing the number of errors at a smaller number of operant reactions. Bromantan increases the tension of motivational component (electric pain irritation avoidance), whereas sydnocarb decreases this component of the operant behavior. None of the two drugs affects the degree of functional activation of the cardiovascular system.
Subject(s)
Amantadine/analogs & derivatives , Central Nervous System Stimulants/pharmacology , Conditioning, Operant/drug effects , Psychotropic Drugs/pharmacology , Sydnones/pharmacology , Amantadine/pharmacology , Animals , Avoidance Learning/drug effects , Catecholamines/urine , Dihydroxyphenylalanine/urine , Dopamine/urine , Heart Rate/drug effects , Male , Rats , Sympathetic Nervous System/drug effects , TimeABSTRACT
Bromantan administration markedly increases the stroke and minute blood volume at a reduced heart rate and peripheral resistance in anaesthetized rats, while the systemic arterial pressure exhibits an insignificant short-time increase. Bromantan also weakly increases the pressor effects of adrenaline and noradrenaline. In anaesthetized cats, bromantan modifies the shape of the amplitude-frequency characteristic of EEG measured in the upper cervical ganglion, reducing (against the initial level) the induced potential in the frequency range of the preganglionic fiber stimulation (1-10 and 25-30 Hz). In freely moving rats, capable of well-learnt Sidman's [correction of Seedman's] operant activity, bromantan showed a reliable tendency to decrease the rate of noradrenaline and adrenaline excretion with urine.
Subject(s)
Adjuvants, Immunologic/pharmacology , Adrenal Glands/drug effects , Amantadine/analogs & derivatives , Cardiovascular System/drug effects , Psychotropic Drugs/pharmacology , Sympathetic Nervous System/drug effects , Amantadine/pharmacology , Animals , Catecholamines/urine , Cats , Conditioning, Operant/drug effects , Dose-Response Relationship, Drug , Hemodynamics/drug effects , Male , RatsABSTRACT
Presents the experience gained in realization of a program of humanitarian care aimed at tuberculosis control in the Voronezh Province of Russia, which was organized by the European Community within the framework of UNO-EEC Echo-Rus/B7-515/93-1806B with participation of the Rudolf Virchow Free University of Berlin. Regular bilateral contacts, well-defined purpose of the program, permanent supervision from both sides over the fulfillment of plans and conditions of the agreement, direct supplies, purchase of equipment and drugs, training of personnel, and introduction of the program in practical public health promoted its successful realization.
Subject(s)
Altruism , International Cooperation , Tuberculosis, Pulmonary/prevention & control , European Union , Germany , Humans , RussiaABSTRACT
Computer method for evaluating the quality of the motivated operator's performance and psychophysiological status was devised and validated. This method can be used for clinical studies of new drugs.
Subject(s)
Psychomotor Performance/drug effects , Psychotropic Drugs/pharmacology , Drug Evaluation/methods , Humans , Microcomputers , Models, Psychological , Motivation , Psychopharmacology , Psychophysiology , SoftwareABSTRACT
Determination of antitryptic activity of blood serum and exudate in patients with tuberculous pleurisy revealed that concentrations of trypsin inhibitors were significantly increased while their activity was markedly decreased (2-3-fold) in the exudate. This indicated exhaustion of the adaptation mechanisms in the inflammatory areas, which required their local correction. Intrapleural administration of contrical increased the body's protective and adaptation potentials and treatment efficiency such as shorter times of intoxication and pleural exudation and less frequency of pronounced concomitant pleural lesions.
