[Statistical evaluation of clinical characteristics and therapeutic management of Hodgkin disease in children over a 10 year period]. / Studiu statistic clinico-terapeutic si evolutiv pe 10 ani al bolii Hodgkin la copil.

UNLABELLED: Hodgkin disease represents the third malign disease like frequency registered to children. Generally, the most cases have been observed to children between 10 and 15 years old. MATERIAL AND METHOD: In our study the patients have been investigated on Pediatric Hemato-Oncologic Department from Clinical and Emergencies Hospital for Children "Sf. Maria" Iasi in a period between 1995 and 2004. RESULTS: The age of patients was between 2 and 17 years, from this group 31 were boys (54.38%) and 21 girls (45.62%). The medium incidence of disease was 5.7 cases per year. Histological analysis indicates 2 cases with lymphocyte prevalence (3.50%), 18 with nodular sclerosis (31.58%), 32 with mixed cellularity (56.14%) and 5 patients with lymphoid depletion (8.78%). Ann-Arbor classification of disease indicates high frequency of stage II on the beginning (38 cases), with primary localization to neck (52 cases) and mediastinum (29 cases). 35 patients have presented biochemical syndrome (stage b). After therapeutically intervention on 55 patients the recovery has been observed, 42 patients didn't present relapse symptoms, 5 patients presented precocious relapse (under 12 months), respectively 6 patients presented tardy relapse (after 12 months). CONCLUSION: The factors for favorable prognosis were: histology with lymphocyte prevalence, stage I or II without systemic signs (FFS 96%), primary localization of disease on one or two groups of ganglions, without hilar and mediastinal zones.

[Clinical features and therapeutics in Hodgkin disease of children]. / Particularitati evolutive si terapeutice ale bolii Hodgkin la copilul mic.

AIM: To investigate the incidence and evolution of Hodgkin disease to children under 5 years age. MATERIAL AND METHOD: The patients have been investigate to Pediatric Hemato-Oncologic Department from Clinical and Emergencies Hospital for Children "Sf. Maria" Iasi in a period between January 1980 and December 2004. In this period 129 patients with Hogkin disease have been hospitalised, and among these 48 patients was under 5 years age (37.20%). RESULTS: From our patients 41 were boys (85.41%) respectively 7 girls (14.59%). Anatomopathologic examination of samples from affected ganglions indicate: 7 patients with lymphocyte prevalence (14.58%), 6 with nodular sclerosis (12.50%), 31 with mixed cellularity (64.58%) and 4 patients with lymphoid depletion (8.34%). Ann-Arbor classification of disease indicate a high incidence of stage II (27 cases--56.25%) in the beginning period than stage I (15 cases--31.25%), III (3 cases--6.25%) and IV (3 cases--6.25%). In 9 cases (18.75%) biochemical syndrome has been observed. Radiotherapy (35 cases--72.91%) and chemotherapy (27.09%) have been used. Failure Free Survival after 5 years for patients with lymphocyte prevalence was 96% for stage I A and II A, 48% for stage III respectively 18% for stage IV. Complications observed were: precocious--medullary toxicity (3 cases), metabolic disorders (4 cases), and late--lung fibrosis with restrictive respiratory dysfunction (2 cases), cardiac dysfunctions (1 case).