ABSTRACT
OBJECTIVE: To determine outcome and prognostic factors in small breed dogs in which hemangiosarcoma was diagnosed and whether outcomes differed between small and large breed dogs with splenic hemangiosarcoma. STUDY DESIGN: Bi-institutional retrospective study. ANIMALS: Forty-three small breed (<20 kg) and 94 large breed client-owned dogs. METHODS: Medical records were reviewed to identify dogs treated with splenectomy for splenic hemangiosarcoma. Data acquired included signalment, preoperative staging, bloodwork results, surgical findings, histopathologic findings, administration of chemotherapy, presence/absence of metastatic disease, and survival time (ST). Cox proportional hazards regression analysis was performed to assess prognostic factors associated with survival. RESULTS: The overall median ST was 116 days and 97 days for small and large breed dogs, respectively. The ST for dogs treated with surgery and chemotherapy was 207 and 139 days for small and large breed dogs, respectively. The disease-free interval (DFI) was 446 and 80 days for small and large breed dogs, respectively. Dog size was associated with DFI (P = .02) but not with ST (P = .09). The presence of metastasis at diagnosis was associated with decreased ST in small (P = .03) and large (P = .0009) breed dogs. Administration of chemotherapy (P = .02) was associated with increased ST (P = .02) in small breed dogs. CONCLUSION: The ST was not different in small and large breed dogs with splenic hemangiosarcoma treated with splenectomy and chemotherapy. CLINICAL SIGNIFICANCE: Prognosis remains poor despite aggressive therapies in small and large breed dogs.
Subject(s)
Dog Diseases/therapy , Hemangiosarcoma/veterinary , Splenectomy/veterinary , Splenic Neoplasms/veterinary , Animals , Body Size , Dog Diseases/diagnosis , Dog Diseases/surgery , Dogs , Female , Hemangiosarcoma/diagnosis , Hemangiosarcoma/surgery , Hemangiosarcoma/therapy , Male , Prognosis , Regression Analysis , Splenic Neoplasms/diagnosis , Splenic Neoplasms/surgery , Splenic Neoplasms/therapy , Treatment OutcomeABSTRACT
This study describes the epidemiology of laboratory-confirmed pandemic influenza H1N1 within north Queensland, Australia. We collected data on all specimens tested for influenza (including H1N1) by polymerase chain reaction between May and August 2009 at Townsville Hospital. Patients requiring admission to hospital and a proportion of non-admitted patients had clinical characteristics recorded. Multi-variable logistic regression analysis was used to identify independent predictors for admission. Patients requiring admission were on average older, less likely to be of Aboriginal or Torres Strait Islander descent and more likely to be pregnant, female or suffer from diabetes mellitus. Oseltamivir provision was significantly higher within the Aboriginal or Torres Strait Islander patient population. However, when the relative sizes of the local Indigenous and non-Indigenous populations were considered, the relative risk of hospital admission for Indigenous people was found to be 7.9 (4.7-13.2) in comparison to non-indigenous.