ABSTRACT
There are presented preliminary results of the analysis of the materials of the register of children and adolescents suffering from Familial Mediterranean Fever in Georgia. The register was created by the "snow ball" method. For today it contains data on 138 patients, 56 (40.6%) males, 82 (59.4%) females, 86 (62.3%) less than 10 year old, 52 (37.7%) 10-18 year old. Almost in all patients the Armenian roots were revealed, both from maternal and paternal sides. Among the MEFV gene mutations M694V (mainly) and also V726A and M680I were the most common ones.
Subject(s)
Cytoskeletal Proteins/genetics , Ethnicity/genetics , Familial Mediterranean Fever/genetics , Adolescent , Armenia , Child , Familial Mediterranean Fever/epidemiology , Familial Mediterranean Fever/pathology , Female , Genotype , Georgia (Republic) , Heterozygote , Humans , Male , Mutation , Phenotype , Polymorphism, Single Nucleotide/genetics , PyrinABSTRACT
Discusses the present state of the problem of universal hygienic standardization. Offers a model for prediction and assessment of comparative hazards of harmful substances upon inhalation and enteral exposure and for calculation of the permissible daily dose. Singles out the main prospective tasks for universal standardization of harmful substances.
