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Hum Exp Toxicol ; 39(7): 920-929, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32054343

ABSTRACT

Cancer continues to be a major cause of mortality globally. Zebrafish present suitable models for studying the mechanisms of genotoxic carcinogens. The aim of this study was to investigate the interaction between oxidant-antioxidant status, apoptosis and immunity in zebrafish that were exposed to three different genotoxic carcinogens methylnitrosourea, dimethylbenzanthracene, benzoapyrene and methylnitrosourea + dimethylbenzanthracene starting from early embryogenesis for 30 days. Lipid peroxidation, nitric oxide levels, superoxide dismutase and glutathione-S-transferase activities and mRNA levels of apoptosis genes p53, bax, casp3a, casp2 and immunity genes fas, tnfα and ifnγ1 were evaluated. The disruption of the oxidant-antioxidant balance accompanied by altered expressions of apoptotic and immunity related genes were observed in different levels according to the carcinogen applied. Noteworthy, ifnγ expressions decreased in all carcinogen-exposed groups. Our results will provide basic data for further carcinogenesis research in zebrafish models.


Subject(s)
9,10-Dimethyl-1,2-benzanthracene/toxicity , Benzo(a)pyrene/toxicity , Carcinogens/toxicity , Methylnitrosourea/toxicity , Animals , Apoptosis/drug effects , Apoptosis Regulatory Proteins/genetics , Embryo, Nonmammalian , Glutathione Transferase/metabolism , Interferon-gamma/genetics , Nitric Oxide/metabolism , Oxidation-Reduction , Oxidative Stress/drug effects , Superoxide Dismutase/metabolism , Zebrafish , Zebrafish Proteins/genetics , Zebrafish Proteins/metabolism
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