Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Elife ; 62017 02 13.
Article in English | MEDLINE | ID: mdl-28177282

ABSTRACT

Acoustic communication is fundamental to social interactions among animals, including humans. In fact, deficits in voice impair the quality of life for a large and diverse population of patients. Understanding the molecular genetic mechanisms of development and function in the vocal apparatus is thus an important challenge with relevance both to the basic biology of animal communication and to biomedicine. However, surprisingly little is known about the developmental biology of the mammalian larynx. Here, we used genetic fate mapping to chart the embryological origins of the tissues in the mouse larynx, and we describe the developmental etiology of laryngeal defects in mice with disruptions in cilia-mediated Hedgehog signaling. In addition, we show that mild laryngeal defects correlate with changes in the acoustic structure of vocalizations. Together, these data provide key new insights into the molecular genetics of form and function in the mammalian vocal apparatus.


Subject(s)
Cilia/physiology , Hedgehog Proteins/metabolism , Larynx/embryology , Signal Transduction , Animals , Larynx/abnormalities , Mice
2.
Curr Opin Neurobiol ; 38: 1-5, 2016 06.
Article in English | MEDLINE | ID: mdl-26789140

ABSTRACT

Vocalizations transmit information to social partners, and mice use these signals to exchange information during courtship. Ultrasonic vocalizations from adult males are tightly associated with their interactions with females, and vary as a function of male quality. Work in the last decade has established that the spectrotemporal features of male vocalizations are not learned, but that female attention toward specific vocal features is modified by social experience. Additionally, progress has been made on elucidating how mouse vocalizations are encoded in the auditory system, and on the olfactory circuits that trigger their production. Together these findings provide us with important insights into how vocal communication can contribute to social interactions.


Subject(s)
Sexual Behavior, Animal/physiology , Ultrasonics , Vocalization, Animal , Animals , Female , Male , Mice , Sex Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...