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1.
Article in Russian | MEDLINE | ID: mdl-7941709

ABSTRACT

Pharmacogenous shifts in EEG spectral density induced by mutually antagonistic noradrenotropic influences (pairs sydnocarb-obsidan and sydnocarb-sonapax) were compared in each of four subjects by means of factor and discriminant analysis. Narrow-band oppositely directed reactions were revealed almost in all classical EEG diapasons in a range of 0.5-30 Hz. Incidence of such reactions, their expression and generalization made it possible to recognize the states, induced by each of the drugs, and EEG reactions to placebo in every subject with high significance. The most pronounced oppositely directed shifts were observed in the band of approximately 20-24 Hz. They were revealed in all the subjects and had an accent of expression in parietal-central areas. Sydnocarb increased the spectral density in this band, obsidan and sonapax decreased it. The obtained data point to the possibility of application of EEG density change in the band of 20-24 Hz over the right parietal area as an EEG marker of the level of activation of noradrenergic neurotransmitter system.


Subject(s)
Adrenergic Agents/pharmacology , Electroencephalography/drug effects , Receptors, Adrenergic/drug effects , Adult , Chi-Square Distribution , Discriminant Analysis , Electroencephalography/instrumentation , Electroencephalography/methods , Electroencephalography/statistics & numerical data , Factor Analysis, Statistical , Female , Humans , Male , Middle Aged , Propranolol/pharmacology , Receptors, Adrenergic/physiology , Sydnones/pharmacology , Sympathomimetics/pharmacology , Thioridazine/pharmacology
2.
Article in Russian | MEDLINE | ID: mdl-2624058

ABSTRACT

As many as 1,851 disease histories of patients belonging to the group of mental disorders of non-psychotic level (code MKB-9 300-317) were analyzed within the framework of the organizational experiment with a purpose of reorganizing the dispensary assistance. The data obtained indicate that the diagnosis and the treatment recommendations are not based enough in all the cases, with social restricting measures dominating over social and protective ones. For such a group of patients, the dispensary follow up is not justified. That is why the available dispensary services require changes in the principles and concrete patterns of their functioning.


Subject(s)
Community Mental Health Centers/organization & administration , Community Mental Health Services/organization & administration , Mental Disorders/diagnosis , Humans , Mental Disorders/rehabilitation , Mental Disorders/therapy , Moscow
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