ABSTRACT
Magnesium deficiency is associated with impaired vascular tone bidirectionally and can lead to both an abnormal increase and abnormal lowering of blood pressure. This article analyzes studies on the relationship between blood pressure parameters and the level of magnesium in the blood. Evidence base for the use of magnesium for correction of vascular tone is presented.
Subject(s)
Blood Pressure , Magnesium Deficiency , Magnesium , Muscle Contraction , Muscle, Smooth, Vascular , Blood Pressure/drug effects , Blood Pressure/physiology , Cardiotonic Agents/therapeutic use , Humans , Magnesium/blood , Magnesium/therapeutic use , Magnesium Deficiency/complications , Magnesium Deficiency/metabolism , Magnesium Deficiency/physiopathology , Magnesium Deficiency/therapy , Muscle Contraction/drug effects , Muscle Contraction/physiology , Muscle, Smooth, Vascular/metabolism , Muscle, Smooth, Vascular/physiopathology , Randomized Controlled Trials as TopicABSTRACT
Safe pharmacotherapy and prevention of arrhythmia is an urgent problem of modern cardiology. Essential micronutrients such as omega-3 polyunsaturated fatty acids (-3 PUF-) significantly contribute to the metabolic processes in cardiomyocytes and cardiac conduction system. This article presents a systematic analysis of anti-arrhythmic effects of omega-3 PUFA and of standardized ethyl esters of omega-3 PUFA. The currently available data indicate two fundamentally different molecular mechanisms of anti-arrhythmic effects: "slow" and "fast" types. Formulation of fundamental prospects of bioinformatic studies of molecular effects of anti-arrhythmic action of omega-3 PUF-s is presented.
Subject(s)
Arrhythmias, Cardiac , Fatty Acids, Omega-3 , Heart Conduction System/drug effects , Myocytes, Cardiac/drug effects , Arachidonic Acid/metabolism , Arrhythmias, Cardiac/drug therapy , Arrhythmias, Cardiac/metabolism , Biotransformation , Cardiovascular Agents/metabolism , Cardiovascular Agents/pharmacology , Clinical Trials as Topic , Cytochromes/metabolism , Docosahexaenoic Acids/metabolism , Docosahexaenoic Acids/pharmacology , Drug Combinations , Eicosapentaenoic Acid/metabolism , Eicosapentaenoic Acid/pharmacology , Fatty Acids, Omega-3/metabolism , Fatty Acids, Omega-3/pharmacology , Heart Conduction System/metabolism , Humans , Ion Channels/metabolism , Micronutrients/metabolism , Micronutrients/pharmacology , Myocytes, Cardiac/metabolism , Receptors, Eicosanoid/metabolism , Receptors, Prostaglandin/metabolismABSTRACT
For people ill with benign hypertension and going through basis hypotensive therapy, taking in Siberian pine nut oil as much as 17,5 g per day, is accompanied by cholesterol-lessening effect, normalization of lipid spectrum of blood, systolic (maximum) benign pressure and lessening of surplus body mass.
