[Results of the use of pumpan preparation in the treatment of severe forms of angina pectoris]. / Rezul'taty primeneniia preparata pumpan v terapii tiazhelykh form stenokardii.

AIM: To assess validity of adjuvant use of pumpan, a homeopathic compound, in patients with unstable angina pectoris and angina of effort (functional class III-IV) receiving conventional treatment. MATERIAL AND METHODS: A direct open controlled trial for 15 months performed initially in hospital, then outpatiently, covered 49 patients with severe angina. Examination of the patients included evaluation of clinical condition and the disease course, lipid metabolism, hemostasis, blood plasma electrolytes, aminotransferases, echo-CG, bicycle exercise, rheoencephalography, ultrasonic dopplerography of head and neck vessels. RESULTS: Pumpan produced a positive effect total nonspecific systemic resistance improved, number of hospitalizations reduced, intracardiac hemodynamics improved in some cases with severe angina. CONCLUSION: Homeopathic compound pumpan can be recommended in the treatment of severe angina to reinforce antianginal effect, improve the disease clinical course, to obtain a hypocoagulative and hypocholesterolemic effect, to normalize intracardiac hemodynamics, to raise myocardial performance and intracoronary reserve as well as nonspecific resistance of the body.

[Hemostatic changes in patients with tumors of the maxillofacial area]. / Izmeneniia gemostaza u bol'nykh s opukholiami cheliustno-litsevoi oblasti.

To study hemostatic impairments in patients with maxillofacial tumors, 131 patients and 30 healthy subjects were examined. The patients were found to develop early hemostatic changes which appeared as a latent DIC syndrome. The mobility of the physiological system of PASA permits the equilibrium of coagulative and anticoagulative mechanisms to be preserved to a definite extent and fairly long. The changes were detected during the formation of prothrombinase, thrombin and during fibrin formation and stabilization in the fibrinolytic system. Hypercoagulation typical of the DIC syndrome at the early stages of tumor was followed by consumption coagulopathic signs and profuse bleeding risk at the T4 and N3 stages.

[The electrocardiographic changes in patients with malignant neoplasms of the maxillofacial area during radio- and chemotherapy]. / Elektrokardiograficheskie izmeneniia u bol'nykh zlokachestvennymi novoobrazovaniiami cheliustno-litsevoi oblasti pri luchevoi i khimioterapii.

Electrocardiographic signs of changes in the myocardium were detected in 93.2 percent of 74 patients with malignant maxillofacial tumors; this was due to the presence of coronary disease, myocardial dystrophy, essential hypertension, respiratory abnormalities. The development and progress of these shifts much depended on radiotherapy and chemoradiotherapy of the tumors. The most frequent findings were deviations in the end section of the ventricular complex, reflecting the metabolic and ischemic changes in the myocardium, associated with a rise in radiation and polychemotherapy dosage. Extracoronarogenic myocardial lesions and coronary disease progression were clinically characterized by augmentation of cardiac insufficiency and various arrhythmias with mild pain syndrome. These specific clinical and electrocardiographic features of myocardial involvement should be borne in mind when choosing and carrying out radio- and polychemoradiotherapy of patients with maxillofacial tumors.

[Changes in the ECG in the surgical treatment of patients with tumors of the maxillofacial area]. / Izmeneniia EKG pri khirurgicheskom lechenii bol'nykh s opukholiami cheliustno-litsevoi oblasti.

The examination has involved 47 patients operated on for maxillofacial tumors. The patients' ages varied from 16 to 74 yrs. They were divided into 2 groups: Group 1 (n = 24) patients were only surgically treated; Group 2 (n = 23) ones were operated on after a course of radiotherapy; ECGs were recorded routinely. ECG changes, not observed before, were detected in the first days after surgery; these were the changes mainly in the repolarization phase. The most manifest were myocardial injury, ischemia, augmentation of electrolytic and hypoxic disorders, myocardial dystrophy. Arrhythmias and blockages of various types developed. These disorders persisted for up to 1-2 weeks and their time course was positive. In the patients operated on after radiotherapy the ECG changes were augmented by the shifts resultant from radiotherapy effects on the myocardium. These data necessitate ECG monitoring of this patient population after surgery, which helps timely detect and treat acute injuries of the myocardium.

[The infectivity of surgical wounds]. / Infitsirovannost' khirurgicheskikh ran

A study was made of microbial contamination of wounds and wound fluid in 114 patients operated upon (clean and conditionally clean operations). Directly before suturing the subcutaneous-fatty cellular tissue no microbes were revealed in 50% of cases, but in 23% of cases potentially pathogenetic microorganisms were isolated. Potential causative agents of purulent infection were revealed in 50% of the patients on the 1st-3rd postoperative days. Suppuration developed in 3 cases only. In a number of cases there were revealed in the wound discharge such microbes which were not detected before the wound was sutured. Sometimes the presence of even numerous potentially-pathogenic microbes in the wound secretion led to no suppuration.