[Informations on psychotropics and their adaptations for patients suffering from mental disorders in France during the SARS-CoV-2 epidemic]. / Informations relatives aux psychotropes et à leurs adaptations éventuelles pour les patients souffrant de troubles psychiques en France pendant l'épidémie à SARS-CoV-2.

The 2019-20 coronavirus pandemic (SARS-CoV-2; severe acute respiratory syndrome coronavirus 2) has dramatic consequences on populations in terms of morbidity and mortality and in social terms, the general confinement of almost half of the world's population being a situation unprecedented in history, which is difficult today to measure the impact at the individual and collective levels. More specifically, it affects people with various risk factors, which are more frequent in patients suffering from psychiatric disorders. Psychiatrists need to know: (i) how to identify, the risks associated with the prescription of psychotropic drugs and which can prove to be counterproductive in their association with COVID-19 (coronavirus disease 2019), (ii) how to assess in terms of benefit/risk ratio, the implication of any hasty and brutal modification on psychotropic drugs that can induce confusion for a differential diagnosis with the evolution of COVID-19. We carried out a review of the literature aimed at assessing the specific benefit/risk ratio of psychotropic treatments in patients suffering from COVID-19. Clinically, symptoms suggestive of COVID-19 (fever, cough, dyspnea, digestive signs) can be caused by various psychotropic drugs and require vigilance to avoid false negatives and false positives. In infected patients, psychotropic drugs should be used with caution, especially in the elderly, considering the pulmonary risk. Lithium and Clozapine, which are the reference drugs in bipolar disorder and resistant schizophrenia, warrant specific attention. For these two treatments the possibility of a reduction in the dosage - in case of minimal infectious signs and in a situation, which does not allow rapid control - should ideally be considered taking into account the clinical response (even biological; plasma concentrations) observed in the face of previous dose reductions. Tobacco is well identified for its effects as an inducer of CYP1A2 enzyme. In a COVID+ patient, the consequences of an abrupt cessation of smoking, particularly related with the appearance of respiratory symptoms (cough, dyspnea), must therefore be anticipated for patients receiving psychotropics metabolized by CYP1A2. Plasma concentrations of these drugs are expected to decrease and can be related to an increase risk of relapse. The symptomatic treatments used in COVID-19 have frequent interactions with the most used psychotropics. If there is no curative treatment for infection to SARS-CoV-2, the interactions of the various molecules currently tested with several classes of psychotropic drugs (antidepressants, antipsychotics) are important to consider because of the risk of changes in cardiac conduction. Specific knowledge on COVID-19 remains poor today, but we must recommend rigor in this context in the use of psychotropic drugs, to avoid adding, in patients suffering from psychiatric disorders, potentially vulnerable in the epidemic context, an iatrogenic risk or loss of efficiency.

[Clinical pharmacy activities coordination in an adult psychiatry unit: Clinical and medicoeconomic impact of pharmaceutical interventions]. / Coordination des activités de pharmacie clinique dans une unité de psychiatrie adulte : impact clinique et médicoéconomique des interventions pharmaceutiques.

OBJECTIVE: Coordination and evaluation of clinical pharmacy activities are necessary to optimize their achievement. Their coordination throughout patient care program was studied in an adult psychiatry unit. The purpose was to evaluate clinical and medicoeconomic impact of pharmaceutical interventions (PIs). METHOD: During five weeks, a full time pharmaceutical presence in the unit allowed medication reconciliation, medication review and multiprofessional meetings. A multiprofessional assessment of PIs impact has been achieved with the CLEO® tool and a determination of direct drug costs was realized. RESULTS: All activities combined, 190 PIs were issued, half during multiprofessional meetings, with an acceptance rate of 67.9% (100% for PIs realized during direct interactions with clinicians). All clinical pharmacy activities demonstrated relevance according to CLEO® scale's dimensions. Around 400€ were saved on direct drug costs and an avoidance of potential prolongation of hospitalization was identified in 6 PIs. CONCLUSION: PIs number, acceptance rate and evaluation results show individual impact of activities, their complementarily and the added value of their coordination. Collaboration between professionals contributed to an efficient and secure medication management. These results are reasons to optimize clinical pharmacy practice in the healthcare facility.