ABSTRACT
22 female patients suffering from idiopathic hirsutism were treated according to Hammerstein's reversed sequential scheme over 12 months. During each treatment cycle of 21 days, the daily medication consisted of 1 coated tablet containing 0.035 mg ethinyl estradiol and 2 mg cyproterone acetate (Diane-35); in addition, the patients received one i.m. injection of 300 mg cyproterone acetate (Androcur-Depot) on the first day of each cycle. This therapy resulted in improvement of the disease in 19 of our patients (86.4%). The transitory, mild side effects observed did not require interruption of the treatment. The reversed sequential scheme making use of the depot form of CPA can successfully be administered in patients with hirsutism.
Subject(s)
Androgen Antagonists , Cyproterone/analogs & derivatives , Cyproterone/administration & dosage , Ethinyl Estradiol/administration & dosage , Hirsutism/drug therapy , Administration, Oral , Adolescent , Adult , Cyproterone/adverse effects , Cyproterone/therapeutic use , Cyproterone Acetate , Drug Administration Schedule , Drug Combinations , Drug Therapy, Combination , Ethinyl Estradiol/adverse effects , Female , Humans , Injections, IntramuscularABSTRACT
Additional materials in food and consumers' goods can produce different allergic reactions. The more important additional materials and reactions produced by them are discussed. They introduce to us the phenomenon of the intolerance and the different cross reactions during treatment of the pathomechanism. The causal clearing up of the intolerance reactions is made by provocation tests, with the help of which pathological reactions may be prevented.
Subject(s)
Dermatitis, Atopic/chemically induced , Food Additives/immunology , Allergens/immunology , Antioxidants/immunology , Cross Reactions/drug effects , Dermatitis, Atopic/diagnosis , Dose-Response Relationship, Immunologic , Drug Tolerance , Flavoring Agents/immunology , Food Coloring Agents/immunology , Food Contamination , Food Preservatives/immunology , HumansABSTRACT
The dermal aspects of an accumulated familiar arsenical late-intoxication -- caused by drinking-water -- are described. We have to expect similar cases to this one even today. At the appearance of multiple M. Bowencentres we have to consider in addition to inner-organic carcinoma, the possibility of an arsenical intoxication as well.
