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Internist (Berl) ; 60(2): 133-140, 2019 02.
Article in German | MEDLINE | ID: mdl-30617701

ABSTRACT

Current guidelines for specialized treatment of diabetes mellitus in the elderly (>65 years old) are primarily based on epidemiologic studies and geriatric assessment of functional health. Yet, age-dependent alterations of glucose metabolism and homeostasis are highly relevant to the pathophysiology of diabetes in the elderly. In this review, we focus on age-related alterations in metabolic pathways and their relevance for the specialized diabetic care in the elderly. We review the role of increasing insulin resistance, age-related ß­cell dysfunction and incretin secretion. The clinical relevance of these effects will also be discussed in regard to the central geriatric syndrome of sarcopenia and antidiabetic drug therapy.


Subject(s)
Aging/metabolism , Blood Glucose/metabolism , Diabetes Mellitus, Type 2/blood , Insulin Resistance , Muscle Proteins/metabolism , Sarcopenia , Aged , Aging/physiology , Diabetes Mellitus, Type 2/drug therapy , Glucose/metabolism , Humans , Hypoglycemic Agents/administration & dosage , Insulin
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